Literature DB >> 32036747

The minimal promoter (P1) of Xist is non-essential for X chromosome inactivation.

Bing Yao1, Mingming Liang1, Hongmei Liu1, Tingting Sui1, Yuning Song1, Yuxin Zhang1, Jichao Deng1, Yuxin Xu1, Liangxue Lai1,2,3,4, Zhanjun Li1.   

Abstract

The previous report shows the minimal promoter (P1) contributes to the Xist RNA activation in cells, while the role of the Xist P1 has not yet been investigated in animal individuals. Here, female Xist P1 knockout rabbits (Xist P1-/-) were generated for the studies. The results showed that there is no significant difference in transmission ratio, Xist and X-linked genes expression, and Xist RNA localization between the female wild type (WT) and Xist P1-/- rabbits, suggesting that P1 is non-essential for Xist expression and XCI in rabbits. Our study has explored the function of Xist P1 in animal level for the first time, and the results provide new ideas for future studies of XCI mechanisms.

Entities:  

Keywords:  CRISPR/Cas9 system; X-chromosome inactivation (XCI); Xist; minimal promoter (P1); rabbit

Mesh：

Substances：

Year:  2020        PMID： 32036747      PMCID： PMC7237162          DOI： 10.1080/15476286.2020.1725725

Source DB:  PubMed          Journal:  RNA Biol        ISSN： 1547-6286            Impact factor:   4.652


  29 in total

1.  Identification and characterization of the human XIST gene promoter: implications for models of X chromosome inactivation.

Authors:  B D Hendrich; R M Plenge; H F Willard
Journal:  Nucleic Acids Res       Date:  1997-07-01       Impact factor: 16.971

Review 2.  The X inactivation centre and X chromosome imprinting.

Authors:  M F Lyon
Journal:  Eur J Hum Genet       Date:  1994       Impact factor: 4.246

3.  A revision of the human XIST gene organization and structural comparison with mouse Xist.

Authors:  Y K Hong; S D Ontiveros; W M Strauss
Journal:  Mamm Genome       Date:  2000-03       Impact factor: 2.957

Review 4.  The X chromosome in development in mouse and man.

Authors:  M Monk
Journal:  J Inherit Metab Dis       Date:  1992       Impact factor: 4.982

5.  Gene action in the X-chromosome of the mouse (Mus musculus L.).

Authors:  M F LYON
Journal:  Nature       Date:  1961-04-22       Impact factor: 49.962

6.  Mapping of the Menkes locus to Xq13.3 distal to the X-inactivation center by an intrachromosomal insertion of the segment Xq13.3-q21.2.

Authors:  Z Tümer; N Tommerup; T Tønnesen; J Kreuder; I W Craig; N Horn
Journal:  Hum Genet       Date:  1992-03       Impact factor: 4.132

7.  A male with two contiguous inactivation centers on a single X chromosome: study of X inactivation and XIST expression.

Authors:  F Muscatelli; D Lena; M G Mettei; M Fontes
Journal:  Hum Mol Genet       Date:  1992-05       Impact factor: 6.150

Review 8.  Mammalian X-chromosome inactivation and the XIST gene.

Authors:  A Ballabio; H F Willard
Journal:  Curr Opin Genet Dev       Date:  1992-06       Impact factor: 5.578

9.  Xist-dependent imprinted X inactivation and the early developmental consequences of its failure.

Authors:  Maud Borensztein; Laurène Syx; Katia Ancelin; Patricia Diabangouaya; Christel Picard; Tao Liu; Jun-Bin Liang; Ivaylo Vassilev; Rafael Galupa; Nicolas Servant; Emmanuel Barillot; Azim Surani; Chong-Jian Chen; Edith Heard
Journal:  Nat Struct Mol Biol       Date:  2017-01-30       Impact factor: 15.369

10.  CRISPR/Cas9-mediated mosaic mutation of SRY gene induces hermaphroditism in rabbits.

Authors:  Yuning Song; Yuanyuan Xu; Mingming Liang; Yuxin Zhang; Mao Chen; Jichao Deng; Zhanjun Li
Journal:  Biosci Rep       Date:  2018-03-21       Impact factor: 3.840
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.