| Literature DB >> 32036656 |
Yinliang Guo1, Zhixian Guo1, Jia-Tian Lu1, Runting Fang1, Si-Cong Chen1, Tuoping Luo1,2.
Abstract
An enantioselective total synthesis of (-)-batrachotoxinin A is accomplished based on a key photoredox coupling reaction and the subsequent local-desymmetrization operation. After the expedient assembly of the highly oxidized steroid skeleton, a delicate sequence of redox manipulations was carried out to deliver a late-stage intermediate on gram scale-and ultimately (-)-batrachotoxinin A in an efficient manner.Entities:
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Year: 2020 PMID： 32036656 DOI： 10.1021/jacs.9b12882
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419