Literature DB >> 32036625

Efficient Pharmacokinetic Modeling Workflow With the MonolixSuite: A Case Study of Remifentanil.

Pauline Traynard1, Géraldine Ayral1, Monika Twarogowska1, Jonathan Chauvin1.   

Abstract

MonolixSuite is a software widely used for model-based drug development. It contains interconnected applications for data visualization, noncompartmental analysis, nonlinear mixed effect modeling, and clinical trial simulations. Its main assets are ease of use via an interactive graphical interface, computation speed, and efficient parameter estimation even for complex models. This tutorial presents a step-by-step pharmacokinetic (PK) modeling workflow using MonolixSuite, including how to visualize the data, set up a population PK model, estimate parameters, and diagnose and improve the model incrementally.
© 2020 LiXOFT. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.

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Year:  2020        PMID： 32036625      PMCID： PMC7180005          DOI： 10.1002/psp4.12500

Source DB:  PubMed          Journal:  CPT Pharmacometrics Syst Pharmacol        ISSN： 2163-8306


  6 in total

1.  Automatic data binning for improved visual diagnosis of pharmacometric models.

Authors:  Marc Lavielle; Kevin Bleakley
Journal:  J Pharmacokinet Pharmacodyn       Date:  2011-10-26       Impact factor: 2.745

2.  Prediction-corrected visual predictive checks for diagnosing nonlinear mixed-effects models.

Authors:  Martin Bergstrand; Andrew C Hooker; Johan E Wallin; Mats O Karlsson
Journal:  AAPS J       Date:  2011-02-08       Impact factor: 4.009

3.  Enhanced Method for Diagnosing Pharmacometric Models: Random Sampling from Conditional Distributions.

Authors:  Marc Lavielle; Benjamin Ribba
Journal:  Pharm Res       Date:  2016-09-07       Impact factor: 4.200

4.  Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. I. Model development.

Authors:  C F Minto; T W Schnider; T D Egan; E Youngs; H J Lemmens; P L Gambus; V Billard; J F Hoke; K H Moore; D J Hermann; K T Muir; J W Mandema; S L Shafer
Journal:  Anesthesiology       Date:  1997-01       Impact factor: 7.892

5.  Basic concepts in population modeling, simulation, and model-based drug development.

Authors:  D R Mould; R N Upton
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2012-09-26

6.  Basic concepts in population modeling, simulation, and model-based drug development-part 2: introduction to pharmacokinetic modeling methods.

Authors:  D R Mould; R N Upton
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2013-04-17
  6 in total
  10 in total

1.  Optimizing Aminoglycoside Dosing Regimens for Critically Ill Pediatric Patients with Augmented Renal Clearance: a Convergence of Parametric and Nonparametric Population Approaches.

Authors:  Sean N Avedissian; Roxane Rohani; John Bradley; Jennifer Le; Nathaniel J Rhodes
Journal:  Antimicrob Agents Chemother       Date:  2021-03-18       Impact factor: 5.191

2.  Osteoporosis treatment with risedronate: a population pharmacokinetic model for the description of its absorption and low plasma levels.

Authors:  B Cardozo; E Karatza; V Karalis
Journal:  Osteoporos Int       Date:  2021-05-17       Impact factor: 4.507

3.  Integration of DNA sequencing with population pharmacokinetics to improve the prediction of irinotecan exposure in cancer patients.

Authors:  Spinel Karas; Amy S Etheridge; Deborah A Nickerson; Nancy J Cox; Karen L Mohlke; Erika Cecchin; Giuseppe Toffoli; Ron H J Mathijssen; Alan Forrest; Robert R Bies; Federico Innocenti
Journal:  Br J Cancer       Date:  2021-10-26       Impact factor: 9.075

4.  Revisiting the guidelines for ending isolation for COVID-19 patients.

Authors:  Yong Dam Jeong; Keisuke Ejima; Kwang Su Kim; Shoya Iwanami; Ana I Bento; Yasuhisa Fujita; Il Hyo Jung; Kazuyuki Aihara; Koichi Watashi; Taiga Miyazaki; Takaji Wakita; Shingo Iwami; Marco Ajelli
Journal:  Elife       Date:  2021-07-27       Impact factor: 8.140

5.  Joint modelling and simulation of M-protein dynamics and progression-free survival for alternative isatuximab dosing with pomalidomide/dexamethasone.

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Journal:  Br J Clin Pharmacol       Date:  2021-11-26       Impact factor: 3.716

6.  A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS-CoV-2.

Authors:  Kwang Su Kim; Keisuke Ejima; Shoya Iwanami; Yasuhisa Fujita; Hirofumi Ohashi; Yoshiki Koizumi; Yusuke Asai; Shinji Nakaoka; Koichi Watashi; Kazuyuki Aihara; Robin N Thompson; Ruian Ke; Alan S Perelson; Shingo Iwami
Journal:  PLoS Biol       Date:  2021-03-22       Impact factor: 8.029

7.  Pharmacokinetic modeling of morphine and its glucuronides: Comparison of nebulization versus intravenous route in healthy volunteers.

Authors:  Thomas Duflot; Tony Pereira; Marie-Pierre Tavolacci; Robinson Joannidès; Frédéric Aubrun; Fabien Lamoureux; Virginie Eve Lvovschi
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2021-11-29

8.  LEAP2 reduces postprandial glucose excursions and ad libitum food intake in healthy men.

Authors:  Christoffer A Hagemann; Malene S Jensen; Stephanie Holm; Lærke S Gasbjerg; Sarah Byberg; Kirsa Skov-Jeppesen; Bolette Hartmann; Jens J Holst; Flemming Dela; Tina Vilsbøll; Mikkel B Christensen; Birgitte Holst; Filip K Knop
Journal:  Cell Rep Med       Date:  2022-03-30

9.  Antiviral Efficacy of Molnupiravir for COVID-19 Treatment.

Authors:  Yuan Bai; Mingwang Shen; Lei Zhang
Journal:  Viruses       Date:  2022-04-06       Impact factor: 5.818

10.  A workflow for the joint modeling of longitudinal and event data in the development of therapeutics: Tools, statistical methods, and diagnostics.

Authors:  Kirill Zhudenkov; Sergey Gavrilov; Alina Sofronova; Oleg Stepanov; Nataliya Kudryashova; Gabriel Helmlinger; Kirill Peskov
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2022-02-21
  10 in total

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