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Literature DB >> 32036601

Neutrophils in the Tumor Microenvironment.

Lingyun Wu¹, Sugandha Saxena¹, Rakesh K Singh².

Abstract

Neutrophils are the first responders to inflammation, infection, and injury. As one of the most abundant leukocytes in the immune system, neutrophils play an essential role in cancer progression, through multiple mechanisms, including promoting angiogenesis, immunosuppression, and cancer metastasis. Recent studies demonstrating elevated neutrophil to lymphocyte ratios suggest neutrophil as a potential therapeutic target and biomarker for disease status in cancer. This chapter will discuss the phenotypic and functional changes in the neutrophil in the tumor microenvironment, the underlying mechanism(s) of neutrophil facilitated cancer metastasis, and clinical potential of neutrophils as a prognostic/diagnostic marker and therapeutic target.

Entities: CellLine Chemical Disease Gene Species

Keywords: Angiogenesis; CXCR2 ligands; IL17; Metastasis; NETs; NLR; Neutrophil; Neutrophil-released proteases; Pro-tumor chemokines; Pro-tumor cytokines; Tumor microenvironment

Mesh：

Year: 2020 PMID： 32036601 PMCID： PMC7325741 DOI： 10.1007/978-3-030-35723-8_1

Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622

176 in total

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Journal: Cancer Discov Date: 2013-05-09 Impact factor: 39.397

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Journal: Cancer Sci Date: 2006-08-17 Impact factor: 6.716

4. Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop.

Authors: Yan Wu; Qiyi Zhao; Chen Peng; Lin Sun; Xue-Feng Li; Dong-Ming Kuang
Journal: J Pathol Date: 2011-08-08 Impact factor: 7.996

5. Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice.

Authors: Bastian Seubert; Barbara Grünwald; Julia Kobuch; Haissi Cui; Florian Schelter; Susanne Schaten; Jens T Siveke; Ngee H Lim; Hideaki Nagase; Nicole Simonavicius; Mathias Heikenwalder; Thomas Reinheckel; Jonathan P Sleeman; Klaus-Peter Janssen; Percy A Knolle; Achim Krüger
Journal: Hepatology Date: 2014-11-24 Impact factor: 17.425

Review 6. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis.

Authors: Arnoud J Templeton; Mairéad G McNamara; Boštjan Šeruga; Francisco E Vera-Badillo; Priya Aneja; Alberto Ocaña; Raya Leibowitz-Amit; Guru Sonpavde; Jennifer J Knox; Ben Tran; Ian F Tannock; Eitan Amir
Journal: J Natl Cancer Inst Date: 2014-05-29 Impact factor: 13.506

7. Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN.

Authors: Zvi G Fridlender; Jing Sun; Samuel Kim; Veena Kapoor; Guanjun Cheng; Leona Ling; G Scott Worthen; Steven M Albelda
Journal: Cancer Cell Date: 2009-09-08 Impact factor: 31.743

Review 8. Metastasis: from dissemination to organ-specific colonization.

Authors: Don X Nguyen; Paula D Bos; Joan Massagué
Journal: Nat Rev Cancer Date: 2009-04 Impact factor: 60.716

9. Neutrophil elastase enhances the proliferation and decreases apoptosis of leukemia cells via activation of PI3K/Akt signaling.

Authors: Rong Yang; Liang Zhong; Xiao-Qun Yang; Kai-Ling Jiang; Liu Li; Hao Song; Bei-Zhong Liu
Journal: Mol Med Rep Date: 2016-03-28 Impact factor: 2.952

Review 10. Neutrophils in Cancer: Two Sides of the Same Coin.

Authors: Eileen Uribe-Querol; Carlos Rosales
Journal: J Immunol Res Date: 2015-12-24 Impact factor: 4.818

31 in total

Review 1. The cancer-natural killer cell immunity cycle.

Authors: Nicholas D Huntington; Joseph Cursons; Jai Rautela
Journal: Nat Rev Cancer Date: 2020-06-24 Impact factor: 60.716

2. Polymorphonuclear Neutrophils and Tumors: Friend or Foe?

Authors: Izabela Szulc-Kielbik; Magdalena Klink
Journal: Exp Suppl Date: 2022

Review 3. Multifunctional Nanosystems Powered Photodynamic Immunotherapy.

Authors: Yunong Ma; Fengfeng Xiao; Cuixia Lu; Liewei Wen
Journal: Front Pharmacol Date: 2022-05-11 Impact factor: 5.988

Review 4. Tumor Microenvironment-A Short Review of Cellular and Interaction Diversity.

Authors: Aleksandra Bożyk; Kamila Wojas-Krawczyk; Paweł Krawczyk; Janusz Milanowski
Journal: Biology (Basel) Date: 2022-06-18

5. Assessing the Prognostic Value of the Neutrophil-to-Lymphocyte Ratio in Stage I Non-Small-Cell Lung Cancer with Complete Resection.

Authors: Wei Liu; Tiantian Zhang; Li Li; Jue Zou; Chunhua Xu
Journal: Can Respir J Date: 2022-06-22 Impact factor: 2.130