O Molinier1, F Goupil2, D Debieuvre3, J-B Auliac4, S Jeandeau5, S Lacroix6, F Martin7, M Grivaux8. 1. Respiratory medicine department, hospital, avenue Rubillard, 72037 Le Mans, France. Electronic address: omolinier@ch-lemans.fr. 2. Respiratory medicine department, hospital, avenue Rubillard, 72037 Le Mans, France. Electronic address: fgoupil@ch-lemans.fr. 3. Pneumology department, Regional Hospital Group Mulhouse-Sud Alsace, Emile Muller hospital, 20 Avenue du Docteur René Laennec, 68070 Mulhouse, France. Electronic address: debieuvred@gmsha.fr. 4. Respiratory medicine department, François Quesnay hospital, 2, boulevard Sully, 78200 Mantes-la-Jolie, France. Electronic address: j-b.auliac@ch-mantes-la-jolie.fr. 5. Respiratory medicine department, National Medical Center MGEN, 4, Les Bains, 23006 Sainte-Feyre, France. Electronic address: sjeandeau@mgen.fr. 6. Respiratory medicine department, Périgueux hospital, 80, avenue Georges-Pompidou, 24000 Périgueux, France. Electronic address: serge.lacroix@ch-perigueux.fr. 7. Pneumology and sleep disorders department, Compiègne-Noyon, Intercommunal Hospital, 8, avenue Henri Adnot, BP 50029, 60321 Compiègne cedex, France. Electronic address: f.martin@ch-compiegnenoyon.fr. 8. Respiratory medicine department, hospital, 6-8, rue Saint Fiacre, BP 218, 77104 Meaux cedex, France. Electronic address: m-grivaux@ch-meaux.fr.
Abstract
OBJECTIVE: To estimate five-year survival in non-small-cell lung cancer (NSCLC) patients according to histology and to identify independent prognostic factors by histology. METHODS: Data were obtained during the KBP-2010-CPHG study, which included all new cases of primary lung cancer diagnosed in 2010 in 104 non-academic hospitals. RESULTS: In all, 3199 patients had adenocarcinoma (ADC), 1852 squamous cell carcinoma (SCC), 754 large cell carcinoma (LCC). Five-year survival was 13.3% [12.1%-14.5%] for ADC, 14.3% [12.7%-16.0%] for SCC, 9.6% [7.6%-11.9%] for LCC (P<0.001). Performance status, weight loss prior to diagnosis and tumour stage were consistently significant independent prognostic factors. Age (>70 years; P=0.004), male gender (P<0.001), and smoking (P<0.001) were independent negative prognostic factors for ADC. Epidermal Growth Factor Receptor (EGFR)-mutation tests, performed in 1638 ADC patients, were positive for 186. Five-year survival was 14.7% [10.3%-21%] and 10.9% [9.4%-12.6%] for mutated and wild-type EGFR, respectively (P<0.001). EFGR mutation was an independent positive prognostic factor (HR=0.5 [0.4-0.6], P<0.001); however, the proportional hazards assumption was not fulfilled and hazards were inverted after 35 months. CONCLUSIONS: Five-year survival in patients managed in French non-academic hospitals for primary NSCLC in 2010 remained poor (<15%), whatever the histologic type. The independent negative prognostic factors for five-year survival were: weight, particularly weight loss prior to diagnosis; smoking (active or former) at diagnosis in ADC and LCC and smoking level at diagnosis in smoker patients with SCC. The independent positive prognostic factors were young age and female gender for ADC.
OBJECTIVE: To estimate five-year survival in non-small-cell lung cancer (NSCLC) patients according to histology and to identify independent prognostic factors by histology. METHODS: Data were obtained during the KBP-2010-CPHG study, which included all new cases of primary lung cancer diagnosed in 2010 in 104 non-academic hospitals. RESULTS: In all, 3199 patients had adenocarcinoma (ADC), 1852 squamous cell carcinoma (SCC), 754 large cell carcinoma (LCC). Five-year survival was 13.3% [12.1%-14.5%] for ADC, 14.3% [12.7%-16.0%] for SCC, 9.6% [7.6%-11.9%] for LCC (P<0.001). Performance status, weight loss prior to diagnosis and tumour stage were consistently significant independent prognostic factors. Age (>70 years; P=0.004), male gender (P<0.001), and smoking (P<0.001) were independent negative prognostic factors for ADC. Epidermal Growth Factor Receptor (EGFR)-mutation tests, performed in 1638 ADCpatients, were positive for 186. Five-year survival was 14.7% [10.3%-21%] and 10.9% [9.4%-12.6%] for mutated and wild-type EGFR, respectively (P<0.001). EFGR mutation was an independent positive prognostic factor (HR=0.5 [0.4-0.6], P<0.001); however, the proportional hazards assumption was not fulfilled and hazards were inverted after 35 months. CONCLUSIONS: Five-year survival in patients managed in French non-academic hospitals for primary NSCLC in 2010 remained poor (<15%), whatever the histologic type. The independent negative prognostic factors for five-year survival were: weight, particularly weight loss prior to diagnosis; smoking (active or former) at diagnosis in ADC and LCC and smoking level at diagnosis in smoker patients with SCC. The independent positive prognostic factors were young age and female gender for ADC.
Authors: Lin Niu; Chunyan Dang; Lin Li; Na Guo; Ying Xu; Xiangling Li; Qian Xu; Luyang Cheng; Li Zhang; Lei Liu Journal: Oncol Lett Date: 2021-06-07 Impact factor: 2.967