Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Age-related changes in liver size and hepatic blood flow. The influence on drug metabolism in the elderly.

Literature DB >> 3203484

Age-related changes in liver size and hepatic blood flow. The influence on drug metabolism in the elderly.

Abstract

The propensity of elderly people to suffer from dose-dependent adverse drug reactions is well known. This may be largely related to reduced drug clearance. Changes in liver size and liver blood flow are probably the main reason for this decline in drug elimination with age. This review focuses on methods of measuring liver size and blood flow, on changes which have been reported in the elderly and on the clinical implications of these changes.

Entities: Species

Mesh：

Year: 1988 PMID： 3203484 DOI： 10.2165/00003088-198815050-00002

Source DB: PubMed Journal: Clin Pharmacokinet ISSN： 0312-5963 Impact factor: 6.447

70 in total

1. Liver blood flow and blood volume following chronic phenobarbitone administration.

Authors: E E Ohnhaus; J T Locher
Journal: Eur J Pharmacol Date: 1975-04 Impact factor: 4.432

2. VARIATION IN THE ACTIVITY OF LIVER MICROSOMAL DRUG-METABOLIZING ENZYMES IN RATS IN RELATION TO THE AGE.

Authors: R KATO; P VASSANELLI; G FRONTINO; E CHIESARA
Journal: Biochem Pharmacol Date: 1964-07 Impact factor: 5.858

3. The use of indocyanine green for the evaluation of hepatic function and blood flow in man.

Authors: B D WIEGAND; S G KETTERER; E RAPAPORT
Journal: Am J Dig Dis Date: 1960-05

4. The disappearance rate of colloidal radio-gold from the circulation and its application to the estimation, of liver blood flow in normal and cirrhotic subjects.

Authors: H VETTER; R FALKNER; A NEUMAYR
Journal: J Clin Invest Date: 1954-12 Impact factor: 14.808

5. Direct measurement of hepatic blood flow in surgical patients: with related observations on hepatic flow dynamics in experimental animals.

Authors: W G SCHENK; J C McDONALD; K McDONALD; T DRAPANAS
Journal: Ann Surg Date: 1962-09 Impact factor: 12.969

6. Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity.

Authors: D J Greenblatt; M Divoll; D R Abernethy; J S Harmatz; R I Shader
Journal: J Pharmacol Exp Ther Date: 1982-01 Impact factor: 4.030

7. Effect of age on the hepatic clearance of propranolol in rats.

Authors: K Iwamoto; J Watanabe; K Araki; N Deguchi; H Sugiyama
Journal: J Pharm Pharmacol Date: 1985-07 Impact factor: 3.765

8. Quantitative liver function in the elderly assessed by galactose elimination capacity, aminopyrine demethylation and caffeine clearance.

Authors: M Schnegg; B H Lauterburg
Journal: J Hepatol Date: 1986 Impact factor: 25.083

9. Evaluation of liver volume and liver function following hepatic resection in man.

Authors: M Zoli; G Marchesini; A Melli; G Viti; A Marra; D Marrano; E Pisi
Journal: Liver Date: 1986-10

10. Predisposing factors in adverse reactions to drugs.

Authors: N Hurwitz
Journal: Br Med J Date: 1969-03-01

36 in total

Review 1. Drug metabolism and ageing.

Authors: M T Kinirons; M S O'Mahony
Journal: Br J Clin Pharmacol Date: 2004-05 Impact factor: 4.335

2. Influence of age and gender on the plasma profiles of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitory activity following multiple doses of lovastatin and simvastatin.

Authors: H Cheng; J D Rogers; A E Sweany; M R Dobrinska; E A Stein; A C Tate; R D Amin; H Quan
Journal: Pharm Res Date: 1992-12 Impact factor: 4.200

Review 3. Hepatic drug metabolism and aging.

Authors: C Durnas; C M Loi; B J Cusack
Journal: Clin Pharmacokinet Date: 1990-11 Impact factor: 6.447

Review 4. Predicting risk of adverse drug reactions in older adults.

Authors: Amanda Hanora Lavan; Paul Gallagher
Journal: Ther Adv Drug Saf Date: 2016-02

5. Quality indicators for in-hospital pharmaceutical care of Dutch elderly patients: development and validation of an ACOVE-based quality indicator set.

Authors: Peter C Wierenga; Joanna E Klopotowska; Susanne M Smorenburg; Hendrikus J van Kan; Yuma A Bijleveld; Marcel G Dijkgraaf; Sophia E de Rooij
Journal: Drugs Aging Date: 2011-04-01 Impact factor: 3.923

Review 6. The hepatic sinusoid in aging and cirrhosis: effects on hepatic substrate disposition and drug clearance.

Authors: David G Le Couteur; Robin Fraser; Sarah Hilmer; Laurent P Rivory; Allan J McLean
Journal: Clin Pharmacokinet Date: 2005 Impact factor: 6.447

7. Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway.

Authors: Katarzyna Furrer; Andreas Rickenbacher; Yinghua Tian; Wolfram Jochum; Anne Greet Bittermann; Andres Käch; Bostjan Humar; Rolf Graf; Wolfgang Moritz; Pierre-Alain Clavien
Journal: Proc Natl Acad Sci U S A Date: 2011-01-31 Impact factor: 11.205