Livia Costa de Oliveira1, Gabriela Travassos Abreu2, Larissa Calixto Lima3, Mariah Azevedo Aredes4, Emanuelly Varea Maria Wiegert3. 1. Nutritionist, Palliative Care Unit, José Alencar Gomes da Silva National Cancer Institute, Rua Visconde de Santa Isabel, 274, Vila Isabel, Rio de Janeiro, RJ, Brazil. lillycostaoliveira@gmail.com. 2. Institutional Development Grant, José Alencar Gomes da Silva National Cancer Institute, Rio de Janeiro, RJ, Brazil. 3. Nutritionist, Palliative Care Unit, José Alencar Gomes da Silva National Cancer Institute, Rua Visconde de Santa Isabel, 274, Vila Isabel, Rio de Janeiro, RJ, Brazil. 4. Student in Continuing Education Course I, José Alencar Gomes da Silva National Cancer Institute, Rio de Janeiro, RJ, Brazil.
Abstract
BACKGROUND: Nutritional impairment is common in cancer patients and adversely affects quality of life (QoL). The aim of this study was to investigate the association between nutritional status and QoL in incurable cancer patients in palliative care. METHODS: A prospective cohort with incurable cancer patients referred to the specialized Palliative Care Unit of the National Cancer Institute in Brazil was conducted. The nutritional risk (NR) was assessed using the Patient-Generated Subjective Global Assessment short form (PG-SGA SF), and cancer cachexia (CC) was defined according to the international consensus. QoL was evaluated using the Quality of Life Questionnaire Core 15 Palliative (QLQ-C15-PAL). Multivariate linear regressions analyses were performed to assess the relationship between the nutritional status and QoL scores. RESULTS: A total of 1039 consecutive patients were included. A high prevalence of NR (85.4%) and CC (78.7%) were observed. The patients with worse nutritional status presented significantly poorer physical, emotional, symptoms domains scales, and overall QoL. CC were significantly associated with QoL scores for dyspnea (p = 0.013), insomnia (p = 0.046), and appetite loss (p = 0.015), while NR were associated with all the QoL domains scales covered in QLQ-C15-PAL. CONCLUSION: Our findings support that impaired nutritional status was associated with poor QoL in incurable cancer patients. NR assessed by PG-SGA SF better reflects physical, emotional, symptom burden, and overall QoL scores. Thus, this tool may contribute in identifying patients at risk of deterioration QoL.
BACKGROUND:Nutritional impairment is common in cancerpatients and adversely affects quality of life (QoL). The aim of this study was to investigate the association between nutritional status and QoL in incurable cancerpatients in palliative care. METHODS: A prospective cohort with incurable cancerpatients referred to the specialized Palliative Care Unit of the National Cancer Institute in Brazil was conducted. The nutritional risk (NR) was assessed using the Patient-Generated Subjective Global Assessment short form (PG-SGA SF), and cancer cachexia (CC) was defined according to the international consensus. QoL was evaluated using the Quality of Life Questionnaire Core 15 Palliative (QLQ-C15-PAL). Multivariate linear regressions analyses were performed to assess the relationship between the nutritional status and QoL scores. RESULTS: A total of 1039 consecutive patients were included. A high prevalence of NR (85.4%) and CC (78.7%) were observed. The patients with worse nutritional status presented significantly poorer physical, emotional, symptoms domains scales, and overall QoL. CC were significantly associated with QoL scores for dyspnea (p = 0.013), insomnia (p = 0.046), and appetite loss (p = 0.015), while NR were associated with all the QoL domains scales covered in QLQ-C15-PAL. CONCLUSION: Our findings support that impaired nutritional status was associated with poor QoL in incurable cancerpatients. NR assessed by PG-SGA SF better reflects physical, emotional, symptom burden, and overall QoL scores. Thus, this tool may contribute in identifying patients at risk of deterioration QoL.
Entities:
Keywords:
Cachexia; Incurable cancer; Malnutrition; Nutritional status; Palliative care; Quality of life
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