Literature DB >> 32031875

Model of Morphogenesis.

Yue Wang1, Andrey Minarsky2, Robert Penner1, Christophe Soulé1,3, Nadya Morozova1,4,5.   

Abstract

We build a theoretical model of morphogenesis. This model describes cell fate in the developing organism using the notion of epigenetic code of each cell. Namely, given the epigenetic spectra of a cell and its neighboring cells, we can determine the corresponding cell event it will perform. This means that the properties of a group of cells (comprising an embryo or its part) at any time point are also known, and thus, the evolution of an embryo can be described. By this strategy, it is possible to establish the tissue, organ, or embryo shapes at any time, starting from a zygote. As an essential part of the model, the formalization of the notion of cell potency is introduced, and the related properties are discussed.

Keywords:  modeling; morphogenesis; signaling

Year:  2020        PMID: 32031875     DOI: 10.1089/cmb.2019.0414

Source DB:  PubMed          Journal:  J Comput Biol        ISSN: 1066-5277            Impact factor:   1.479


  1 in total

1.  Two metrics on rooted unordered trees with labels.

Authors:  Yue Wang
Journal:  Algorithms Mol Biol       Date:  2022-06-06       Impact factor: 1.721

  1 in total

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