Peter Selmer Rønningen1,2, Trygve Berge1, Magnar Gangås Solberg1,2, Steve Enger1, Ståle Nygård3, Mohammad Osman Pervez2,4, Eivind Bjørkan Orstad4, Brede Kvisvik2,4, Erika Nerdrum Aagaard2,4, Helge Røsjø2,5, Arnljot Tveit1,2, Kjetil Steine2,4. 1. Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Postbox 800, 3004 Drammen, Norway. 2. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Postbox 1171, Blindern, 0318 Oslo, Norway. 3. Department of Informatics, Faculty of Mathematics and Natural Sciences, University of Oslo, Postbox 1080, Blindern, 0316 Oslo, Norway. 4. Department of Cardiology, Division of Medicine Akershus University Hospital, Postbox 1000, 1478 Lørenskog, Norway. 5. Division for Research and Innovation, Akershus University Hospital, Postbox 1000, 1478 Lørenskog, Norway.
Abstract
AIMS: The current study aimed to describe normal values of left atrial (LA) volumes and LA emptying fraction (LAEF) in a large sample in their mid-60s from the general population and to explore sex differences. METHODS AND RESULTS: In the Akershus Cardiac Examination (ACE) 1950 Study, body surface area-indexed LA maximum (LAVimax) and minimum (LAVimin) volumes and LAEF were measured in 3489 individuals aged 63.9 ± 0.6 years from the general population. A healthy group of 832 individuals was defined. Data are presented as mean ± standard deviation (SD) and a normal range of mean ± 2 SD. T-tests were used for comparisons. In the healthy group, mean LAVimax was 25.5 ± 6.2 mL/m2 and the normal range was 13.1-37.9 mL/m2. Men had significantly larger body surface area-indexed volumes than women, but there was no difference in LAEF. The mean LAVimax for healthy men was 26.4 ± 6.5 mL/m2, for healthy women 24.9 ± 5.8 mL/m2 (P < 0.001) and the upper normal limits were 39.4 and 36.5 mL/m2, respectively. In the healthy group, 13.0% of all men and 5.4% of all women had LAVimax above the current upper normal limit of 34 mL/m2. CONCLUSION: A large proportion of healthy individuals, in particular men, had LAVimax >34 mL/m2. Our findings suggest that the recommended cut-off may be too low at the age of 65 years and above and that sex-specific cut-offs should be considered. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: The current study aimed to describe normal values of left atrial (LA) volumes and LA emptying fraction (LAEF) in a large sample in their mid-60s from the general population and to explore sex differences. METHODS AND RESULTS: In the Akershus Cardiac Examination (ACE) 1950 Study, body surface area-indexed LA maximum (LAVimax) and minimum (LAVimin) volumes and LAEF were measured in 3489 individuals aged 63.9 ± 0.6 years from the general population. A healthy group of 832 individuals was defined. Data are presented as mean ± standard deviation (SD) and a normal range of mean ± 2 SD. T-tests were used for comparisons. In the healthy group, mean LAVimax was 25.5 ± 6.2 mL/m2 and the normal range was 13.1-37.9 mL/m2. Men had significantly larger body surface area-indexed volumes than women, but there was no difference in LAEF. The mean LAVimax for healthy men was 26.4 ± 6.5 mL/m2, for healthy women 24.9 ± 5.8 mL/m2 (P < 0.001) and the upper normal limits were 39.4 and 36.5 mL/m2, respectively. In the healthy group, 13.0% of all men and 5.4% of all women had LAVimax above the current upper normal limit of 34 mL/m2. CONCLUSION: A large proportion of healthy individuals, in particular men, had LAVimax >34 mL/m2. Our findings suggest that the recommended cut-off may be too low at the age of 65 years and above and that sex-specific cut-offs should be considered. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Riccardo M Inciardi; Andrea Bonelli; Tor Biering-Sorensen; Matteo Cameli; Matteo Pagnesi; Carlo Mario Lombardi; Scott D Solomon; Marco Metra Journal: Eur J Heart Fail Date: 2022-06-06 Impact factor: 17.349