| Literature DB >> 32031030 |
Yasmin Ben-Dali1, Mariam H Hleuhel1, Caspar da Cunha-Bang1,2, Christian Brieghel1, Christian B Poulsen2, Erik Clasen-Linde3, Hans H N Bentzen4, Henrik Frederiksen5, Ilse Christiansen6, Linda H Nielsen7, Lisbeth Enggaard8, Marie Helleberg9, Michael Clausen10, Mikael Frederiksen11, Robert S Pedersen12, Carsten U Niemann1, Michael A Andersen1.
Abstract
Richter's transformation (RT) refers to the development of an aggressive lymphoma in patients with chronic lymphocytic leukemia (CLL). Approximately, 2-10% of patients with CLL develop RT, most often as diffuse large B-cell lymphoma. To assess the incidence of RT, we examined risk factors for RT and death among patients with RT in a nationwide CLL cohort (from 2008 to 2016). Among 3772 patients, 113 had biopsy-proven RT. With a median follow-up of 4.3 years, the 5-year cumulative incidence of RT was 2.8%. Advanced Binet stage (B/C) (p<.001), unmutated IGHV (p<.001), and del(17p) (p<.001) were independently associated with risk of developing RT. Half of the patients with RT (49%) were treatment-naïve prior to transformation and demonstrated longer survival after RT compared to patients previously treated for CLL (6.1 vs. 2.8 years, p=.03). Whether this finding could be explained by a higher proportion of clonally unrelated RT among treatment-naïve patients, remain to be addressed.Entities:
Keywords: Chronic lymphocytic leukemia; Hodgkin lymphoma; Richter’s transformation; diffuse large B-cell lymphoma; prognostication
Mesh：
Year: 2020 PMID： 32031030 DOI： 10.1080/10428194.2020.1719092
Source DB: PubMed Journal: Leuk Lymphoma ISSN： 1026-8022