| Literature DB >> 3203046 |
T Pullar1, O Myall, J R Haigh, J R Lowe, J S Dixon, H A Bird.
Abstract
The effect of 5 days treatment with allopurinol (300 mg) on the pharmacokinetics of indomethacin at steady-state was investigated in eight patients. Allopurinol produced no significant effect on the indomethacin serum concentration-time curve. Allopurinol did not alter significantly the amounts of indomethacin excreted in the urine within 8 h. However, the urinary ratio of N-deschlorobenzoylindomethacin to indomethacin was reduced significantly by allopurinol administration (P less than 0.05).Entities:
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Year: 1988 PMID： 3203046 PMCID： PMC1386454 DOI： 10.1111/j.1365-2125.1988.tb05263.x
Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335