Seung-Sik Hwang1, Ki Ok Ahn2, Sang Do Shin3, Young Sun Ro4, Sun Young Lee5, Ju Ok Park6, Joohyun Suh7. 1. Department of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea. Electronic address: cyberdoc@snu.ac.kr. 2. Department of Emergency Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Republic of Korea. Electronic address: arendt75@gmail.com. 3. Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Republic of Korea. 4. Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Republic of Korea. 5. Department of Emergency Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Dispatch Center, National Fire Agency, Sejong, Republic of Korea. 6. Department of Emergency Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwasung-si, Gyounggi, Republic of Korea. 7. Department of Emergency Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Republic of Korea.
Abstract
BACKGROUND: We compared the temporal trends in survival and neurological outcomes after out-of-hospital cardiac arrest (OHCA) in men and women. METHODS: A nationwide, population-based observational study enrolled adults with OHCA of presumed cardiac origin from 2008 to 2015. The main outcomes were survival and neurological recovery. We performed trend analyses of potential risk factors and outcomes. Adjusted odd ratios (aOR) were calculated using multivariate logistic regression analysis after adjusting for confounders. To assess whether outcomes had improved over time in both sexes, we calculated the yearly risk-adjusted survival rates and neurological recovery rate for the study period. RESULTS: We included 121,900 patients in the final analysis. Women comprised 36.2% of the patients. During the study, survival improved in both sexes, from 3.2% to 7.9% in men and from 1.8% to 3.7% in women. Neurological recovery improved in men from 1.1% to 5.9% and in women from 0.7% to 2.3%. The risk-adjusted survival rates increased significantly in men from 3.2% in 2008 to 5.7% in 2015 (p for trend <0.01); these rates did not increase to the same degree in women (from 1.8% in 2008 to 3.4% in 2015; p for trend <0.01). After adjusting for confounders, the risk-adjusted neurological recovery rate increased from 1.1% in 2008 to 4.3% in 2015 (p for trend <0.01) in men. This improvement trend was lower in women (from 0.7% in 2008 to 1.5% in 2015, p for trend <0.01). CONCLUSIONS: The outcomes of OHCA improved in both sexes during the study period. The degree of improvement in outcomes was higher in men than in women.
BACKGROUND: We compared the temporal trends in survival and neurological outcomes after out-of-hospital cardiac arrest (OHCA) in men and women. METHODS: A nationwide, population-based observational study enrolled adults with OHCA of presumed cardiac origin from 2008 to 2015. The main outcomes were survival and neurological recovery. We performed trend analyses of potential risk factors and outcomes. Adjusted odd ratios (aOR) were calculated using multivariate logistic regression analysis after adjusting for confounders. To assess whether outcomes had improved over time in both sexes, we calculated the yearly risk-adjusted survival rates and neurological recovery rate for the study period. RESULTS: We included 121,900 patients in the final analysis. Women comprised 36.2% of the patients. During the study, survival improved in both sexes, from 3.2% to 7.9% in men and from 1.8% to 3.7% in women. Neurological recovery improved in men from 1.1% to 5.9% and in women from 0.7% to 2.3%. The risk-adjusted survival rates increased significantly in men from 3.2% in 2008 to 5.7% in 2015 (p for trend <0.01); these rates did not increase to the same degree in women (from 1.8% in 2008 to 3.4% in 2015; p for trend <0.01). After adjusting for confounders, the risk-adjusted neurological recovery rate increased from 1.1% in 2008 to 4.3% in 2015 (p for trend <0.01) in men. This improvement trend was lower in women (from 0.7% in 2008 to 1.5% in 2015, p for trend <0.01). CONCLUSIONS: The outcomes of OHCA improved in both sexes during the study period. The degree of improvement in outcomes was higher in men than in women.
Authors: Claire A Hawkes; Inès Kander; Abraham Contreras; Chen Ji; Terry P Brown; Scott Booth; A Niroshan Siriwardena; Rachael T Fothergill; Julia Williams; Nigel Rees; Estelle Stephenson; Gavin D Perkins Journal: Resusc Plus Date: 2022-05-30