Growth related changes in protein synthesis and in a 25 kDa protein of Ehrlich ascites tumor cells.

The decrease of the in vivo growth rate of the Ehrlich ascites tumor after intraperitoneal injection of carcinoma cells into mice is correlated with (1) a decline in the overall rate of cellular protein synthesis, (2) a corresponding decrease of the activity of the cytosolic fraction to stimulate in vitro polysomal protein synthesis, (3) the abundance and phosphorylation of a 25 kDa protein. The results are discussed with respect to correlations between the regulation of protein synthesis and cell proliferation.