Kasirajan Kasinathan1, Balaji Murugesan2, Nithya Pandian2, Sundrarajan Mahalingam2, Balamurugan Selvaraj3, Karunakaran Marimuthu4. 1. Thin Film and Nanoscience Research Lab, PG and Research Department of Physics, Alagappa Government Arts College, Affiliated by Alagappa University, Karaikudi 630 003, India. 2. Advanced Green Chemistry Lab, Department of Industrial Chemistry, School of Chemical Sciences, Alagappa University, Karaikudi 630 003, Tamil Nadu, India. 3. PG and Research Department of Physics, AVVM Sri Pushpam College, Poondi, Thanjavur, Tamil Nadu, India. 4. Thin Film and Nanoscience Research Lab, PG and Research Department of Physics, Alagappa Government Arts College, Affiliated by Alagappa University, Karaikudi 630 003, India.. Electronic address: tvdkaruna@gmail.com.
Abstract
A bacterial and viral infection causes life threatening diseases owing to the abuse of antibiotics and the development of antibiotic resistance microbes. Currently, biopolymers have been considered as the most promising materials in the medical field. Herein, the biogenic chitosan-functionalized MoS2 nanocomposite was prepared by the hydrothermal method with the liquid exfoliation process. The X-ray diffraction (XRD) results of chitosan-MoS2 hybrid nanocomposite revealed that MoS2 nanoparticle was found to be 42 nm with a hexagonal crystal structure. FTIR and Raman spectrum revealed that the nitrogen functionalities in the chitosan interacted with MoS2 to form the nanocomposite. The XPS spectrum of chitosan-MoS2 nanocomposite confirms that C, N, O, Mo, and S exist in the nanocomposite. Thermal gravimetric analysis (TGA) and Differential thermal analysis (DTA) analysis showed that the chitosan-MoS2 nanocomposite has higher thermal stability up to 600 °C. In the antibacterial application the chitosan-MoS2 hybrid nanocomposite shows zones of inhibition against S. aureus as 22, 28, and 32 mm, and against E. coli as 26, 30, and 35 mm. In the anticancer analysis, chitosan-MoS2 hybrid nanocomposites showed a maximum cell inhibition of 65.45% at 100 μg/mL-1, resulting in the most significant MCF-7 cell inhibition.
A bacterial and viral infection causes life threatening diseases owing to the abuse of antibiotics and the development of antibiotic resistance microbes. Currently, biopolymers have been considered as the most promising materials in the medical field. Herein, the biogenic chitosan-functionalized n class="Chemical">MoS2 nanocomposite was prepared by the hydrothermal method with the liquid exfoliation process. The X-ray diffraction (XRD) results of chitosan-MoS2 hybrid nanocomposite revealed that MoS2 nanoparticle was found to be 42 nm with a hexagonal crystal structure. FTIR and Raman spectrum revealed that the nitrogen functionalities in the chitosan interacted with MoS2 to form the nanocomposite. The XPS spectrum of chitosan-MoS2 nanocomposite confirms that C, N, O, Mo, and S exist in the nanocomposite. Thermal gravimetric analysis (TGA) and Differential thermal analysis (DTA) analysis showed that the chitosan-MoS2 nanocomposite has higher thermal stability up to 600 °C. In the antibacterial application the chitosan-MoS2 hybrid nanocomposite shows zones of inhibition against S. aureus as 22, 28, and 32 mm, and against E. coli as 26, 30, and 35 mm. In the anticancer analysis, chitosan-MoS2 hybrid nanocomposites showed a maximum cell inhibition of 65.45% at 100 μg/mL-1, resulting in the most significant MCF-7 cell inhibition.
Authors: Weslley Souza Paiva; Francisco Ernesto de Souza Neto; Moacir Fernandes Queiroz; Lucas Alighieri Neves Costa Batista; Hugo Alexandre Oliveira Rocha; Anabelle Camarotti de Lima Batista Journal: Molecules Date: 2021-12-28 Impact factor: 4.411