Yago Leira1,2,3, Álvaro Carballo2, Marco Orlandi1, José Manuel Aldrey4,5, Juan Manuel Pías-Peleteiro4,5, Federico Moreno1, Laura Vázquez-Vázquez4,5, Francisco Campos5, Francesco D'Aiuto1, José Castillo5, Tomás Sobrino5, Juan Blanco2,3. 1. Periodontology Unit, UCL Eastman Dental Institute and NIHR UCLH Biomedical Research Centre, University College London, London, UK. 2. Periodontology Unit, Faculty of Medicine and Odontology, University of Santiago de Compostela, Santiago de Compostela, Spain. 3. Medical-Surgical Dentistry (OMEQUI) Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. 4. Dementia Unit, Department of Neurology, Clinical University Hospital, Santiago de Compostela, Spain. 5. Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Abstract
AIM: To investigate whether periodontitis is associated with amyloid beta (Aβ) peptides and whether systemic inflammation could act as a potential mediator of this link. MATERIALS AND METHODS: A case-control study was designed including 75 patients with periodontitis (cases) and 75 age-balanced and gender-matched participants without periodontitis (controls). Full-mouth periodontal evaluation was performed in all participants. Demographic, clinical and behaviour data were also recorded. Fasting blood samples were collected, and serum levels of interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), Aβ1-40 and Aβ1-42 were determined. RESULTS: Cases showed higher levels of IL-6 (8.7 ± 3.2 vs. 4.8 ± 0.5 pg/ml), hs-CRP (3.3 ± 1.2 vs. 0.9 ± 0.7 mg/L), Aβ1-40 (37.3 ± 6.0 vs. 30.3 ± 1.8 pg/ml) and Aβ1-42 (54.5 ± 10.6 vs. 36.5 ± 10.0 pg/ml) when compared to controls (all p < .001). Diagnosis of periodontitis was statistically significantly associated with circulating Aβ1-40 ( β coefficient adjusted = 6.9, 95% CI: 5.4-8.3; p < .001) and Aβ1-42 ( β coefficient adjusted = 17.8, 95% CI: 14.4-21.3; p < .001). Mediation analysis confirmed hs-CRP and IL-6 as mediators of this association. CONCLUSIONS: Periodontitis is associated with increased peripheral levels of Aβ. This finding could be explained by enhanced systemic inflammation that can be seen in patients with periodontitis.
AIM: To investigate whether periodontitis is associated with amyloid beta (Aβ) peptides and whether systemic inflammation could act as a potential mediator of this link. MATERIALS AND METHODS: A case-control study was designed including 75 patients with periodontitis (cases) and 75 age-balanced and gender-matched participants without periodontitis (controls). Full-mouth periodontal evaluation was performed in all participants. Demographic, clinical and behaviour data were also recorded. Fasting blood samples were collected, and serum levels of interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), Aβ1-40 and Aβ1-42 were determined. RESULTS: Cases showed higher levels of IL-6 (8.7 ± 3.2 vs. 4.8 ± 0.5 pg/ml), hs-CRP (3.3 ± 1.2 vs. 0.9 ± 0.7 mg/L), Aβ1-40 (37.3 ± 6.0 vs. 30.3 ± 1.8 pg/ml) and Aβ1-42 (54.5 ± 10.6 vs. 36.5 ± 10.0 pg/ml) when compared to controls (all p < .001). Diagnosis of periodontitis was statistically significantly associated with circulating Aβ1-40 ( β coefficient adjusted = 6.9, 95% CI: 5.4-8.3; p < .001) and Aβ1-42 ( β coefficient adjusted = 17.8, 95% CI: 14.4-21.3; p < .001). Mediation analysis confirmed hs-CRP and IL-6 as mediators of this association. CONCLUSIONS:Periodontitis is associated with increased peripheral levels of Aβ. This finding could be explained by enhanced systemic inflammation that can be seen in patients with periodontitis.
Authors: Yago Leira; Clara Domínguez; Pablo Ameijeira; Esteban López-Arias; Paulo Ávila-Gómez; María Pérez-Mato; Tomás Sobrino; Francisco Campos; Juan Blanco; Rogelio Leira Journal: Sci Rep Date: 2021-01-13 Impact factor: 4.379
Authors: Pablo Galindo-Moreno; Lucia Lopez-Chaichio; Miguel Padial-Molina; Gustavo Avila-Ortiz; Francisco O'Valle; Andrea Ravida; Andres Catena Journal: Clin Oral Investig Date: 2021-12-08 Impact factor: 3.573
Authors: João Botelho; Yago Leira; João Viana; Vanessa Machado; Patrícia Lyra; José Manuel Aldrey; Juan Manuel Pías-Peleteiro; Juan Blanco; Tomás Sobrino; José João Mendes Journal: Nutrients Date: 2021-03-12 Impact factor: 5.717