Literature DB >> 32027173

Utilizing the CF2H moiety as a H-bond-donating group in drug discovery.

Yossi Zafrani1, Sigal Saphier1, Eytan Gershonov1.   

Abstract

Entities:  

Keywords:  bioisostere; difluoromethyl; drug design; hydrogen bond

Mesh：

Substances：

Year:  2020        PMID： 32027173     DOI： 10.4155/fmc-2019-0309

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


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  3 in total

1.  Decarbonylative Fluoroalkylation at Palladium(II): From Fundamental Organometallic Studies to Catalysis.

Authors:  Naish Lalloo; Christian A Malapit; S Maryamdokht Taimoory; Conor E Brigham; Melanie S Sanford
Journal:  J Am Chem Soc       Date:  2021-10-28       Impact factor: 15.419

2.  2-Difluoromethylpyridine as a bioisosteric replacement of pyridine-N-oxide: the case of quorum sensing inhibitors.

Authors:  Truong Thanh Tung; Thang Nguyen Quoc
Journal:  RSC Med Chem       Date:  2021-09-08

3.  Nickel and Copper Catalyzed ipso-Phosphonodifluoromethylation of Arylboronic Acids with BrCF2 P(O)(OEt)2 for the Synthesis of Phosphonodifluoromethylarenes.

Authors:  Alexander Knieb; Vinayak Krishnamurti; Xanath Ispizua-Rodriguez; G K Surya Prakash
Journal:  Chemistry       Date:  2022-06-08       Impact factor: 5.020
  3 in total

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