O Olanrewaju1, S Stockwell2, B Stubbs3, L Smith4. 1. Anglia Ruskin University, Cambridge, UK. olawale.olanrewaju@pgr.anglia.ac.uk. 2. Anglia Ruskin University, Cambridge, UK. 3. Positive Ageing Research Institute, FHSCME, Anglia Ruskin University, South London and Maudsley Foundation NHS Trust, London, UK. 4. The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK.
Abstract
BACKGROUND: Physical activity can improve cognitive function of older adults, but the influence of sedentary behaviour on cognition is less clear. This systematic review investigated associations between sedentary behaviour and cognitive function in older adults without dementia, and possible mechanisms involved. METHODS: Major databases were searched for studies in English between 01/01/1999 and 31/10/2019. The systematic review followed COSMOS-E guideline and a pre-registered protocol (CRD42019122229). Risk of bias was assessed using NICE Quality appraisal checklist. Findings were narratively synthesized and presented. FINDINGS: Eighteen studies comprised of 13 cross-sectional and five longitudinal analyses (n = 40,228). Evidence suggested varied associations between varied sedentary behaviours and cognitive function in older adults. 50% of study analyses did not control for physical activity. 3/18 studies demonstrated associations between higher sedentary levels and lower levels of brain biomarkers, while 1/18 showed auto-regulatory effect in the left hippocampus. Conducting a meta-analysis was not justifiable due to considerable methodological, participant, outcome and exposure heterogeneity. CONCLUSION: There is a lack of clarity about the overall and independent association between sedentary behaviour and cognition in older age. Underlying mechanisms are similar to physical activity and probably multi-modal. More studies with robust designs and methodology are needed to confirm effect of sedentary behaviour on cognition.
BACKGROUND: Physical activity can improve cognitive function of older adults, but the influence of sedentary behaviour on cognition is less clear. This systematic review investigated associations between sedentary behaviour and cognitive function in older adults without dementia, and possible mechanisms involved. METHODS: Major databases were searched for studies in English between 01/01/1999 and 31/10/2019. The systematic review followed COSMOS-E guideline and a pre-registered protocol (CRD42019122229). Risk of bias was assessed using NICE Quality appraisal checklist. Findings were narratively synthesized and presented. FINDINGS: Eighteen studies comprised of 13 cross-sectional and five longitudinal analyses (n = 40,228). Evidence suggested varied associations between varied sedentary behaviours and cognitive function in older adults. 50% of study analyses did not control for physical activity. 3/18 studies demonstrated associations between higher sedentary levels and lower levels of brain biomarkers, while 1/18 showed auto-regulatory effect in the left hippocampus. Conducting a meta-analysis was not justifiable due to considerable methodological, participant, outcome and exposure heterogeneity. CONCLUSION: There is a lack of clarity about the overall and independent association between sedentary behaviour and cognition in older age. Underlying mechanisms are similar to physical activity and probably multi-modal. More studies with robust designs and methodology are needed to confirm effect of sedentary behaviour on cognition.
Authors: Pankaja Desai; Denis Evans; Klodian Dhana; Neelum T Aggarwal; Robert S Wilson; Elizabeth McAninch; Kumar B Rajan Journal: JAMA Netw Open Date: 2021-08-02
Authors: David A Raichlen; Yann C Klimentidis; M Katherine Sayre; Pradyumna K Bharadwaj; Mark H C Lai; Rand R Wilcox; Gene E Alexander Journal: Proc Natl Acad Sci U S A Date: 2022-08-22 Impact factor: 12.779
Authors: Sanmei Chen; Tao Chen; Takanori Honda; Yu Nofuji; Hiro Kishimoto; Kenji Narazaki Journal: Int J Environ Res Public Health Date: 2022-02-11 Impact factor: 3.390
Authors: Carlijn M Maasakkers; Jurgen A H R Claassen; Siobhan Scarlett; Dick H J Thijssen; Rose Anne Kenny; Joanne Feeney; René J F Melis Journal: Prev Med Rep Date: 2021-07-01
Authors: Patricio Solis-Urra; Julio Plaza-Diaz; Ana Isabel Álvarez-Mercado; Fernando Rodríguez-Rodríguez; Carlos Cristi-Montero; Juan Pablo Zavala-Crichton; Jorge Olivares-Arancibia; Javier Sanchez-Martinez; Francisco Abadía-Molina Journal: Int J Environ Res Public Health Date: 2020-04-11 Impact factor: 3.390