Predictors of Symptom Burden in Patients with COPD on LAMA Monotherapy: Multivariable Analysis of a Claims-Linked Survey Study.

INTRODUCTION: Many patients with chronic obstructive pulmonary disease (COPD) prescribed long-acting muscarinic antagonist (LAMA) monotherapy remain symptomatic. This multivariable analysis of a previously reported claims-linked, cross-sectional survey assessed symptom burden measured by the COPD assessment test (CAT) in patients treated with LAMA monotherapy.
METHODS: Eligible patients aged ≥ 40 years with COPD (≥ 2 International Classification of Diseases-10th Revision-Clinical Modification [ICD-10-CM] diagnosis codes ≥ 30 days apart during the 12-month baseline period) and ≥ 2 claims for LAMA monotherapy in the latter half of the baseline period were identified using claims data from the Optum Research Database. Patients completed a survey and 7-day daily diary; baseline clinical characteristics and resource utilization were assessed from claims data. Association between symptom burden and baseline characteristics was assessed using generalized linear regression modeling with normal distribution and identity link.
RESULTS: Overall, 433 patients prescribed LAMA monotherapy with claims-linked survey and diary data were included in the analysis. Most patients (85.5%) had a mean CAT score ≥ 10; 39.0% had scores ≥ 21. Overall, the factors most related to a clinically meaningful increase in CAT score (≥ 2 points) were being diagnosed with COPD for > 5 years and being a current smoker (2.25 points, P = 0.003 and 2.22 points, P = 0.025, respectively).
CONCLUSIONS: Results demonstrate that many patients with COPD receiving LAMA monotherapy remain symptomatic, especially those diagnosed > 5 years ago or those who continue to smoke. Use of patient-reported outcomes such as the CAT should be considered part of routine visits for patients with COPD. FUNDING: GlaxoSmithKline (GSK study number 205862 [HO-16-16642]).

Introduction

Chronic obstructive pulmonary disease (COPD) is one of the most common chronic diseases, and is a leading cause of morbidity and mortality worldwide [1]. In the United States, it is estimated to affect 15.7 million individuals and is the third leading cause of death [2]. It has a high clinical and economic burden, is a leading cause of hospitalization and emergency department (ED) visits and contributes significantly to both direct and indirect healthcare costs [1, 3]. The most common symptoms experienced by patients with COPD include dyspnea, coughing, sputum production, wheezing, chest tightness, and chest congestion [4]. Symptom burden differs depending on the patient population and disease severity [4]; however, most individuals perceive it as a significant ongoing challenge in their day-to-day activities [5]. Bronchodilation with a long-acting muscarinic antagonist (LAMA), a long-acting β2-agonist (LABA), or a combination of the two, is the mainstay of pharmacological therapy for COPD [6]. However, a significant proportion of patients may not achieve adequate disease control with monotherapy alone [7]. A recent claims-linked survey study of a US population of patients with COPD receiving LAMA monotherapy found that 71.6% remained symptomatic based on ≥ 2 COPD-related patient-reported burden of illness measures. For these patients, escalation to LAMA/LABA combination therapy is recommended, with escalation to triple therapy (a combination of a LAMA, LABA, and inhaled corticosteroids [8]) if symptoms persist or if patients are at high risk for a COPD exacerbation [6].

In order to obtain reliable and valid information on the symptom burden of COPD, a comprehensive assessment of symptoms is needed [6]. The use of the modified Medical Research Council (mMRC) dyspnea scale and the COPD assessment test (CAT) are recommended patient-reported outcome (PRO) measures of symptom burden in the 2019 global initiative for chronic obstructive lung disease (GOLD) report [6]. The mMRC dyspnea scale is used to assess breathlessness in patients with COPD and has been demonstrated to correlate well with other measures of health status [6, 9].

The CAT has been demonstrated to be a simple and reliable measure of overall COPD-related health status, and aims to enhance physician−patient communication by promoting concordance between the physician and patient in terms of perception of the severity and impact of the patient’s disease. The CAT is an eight-item validated questionnaire that measures the most salient symptoms of COPD, including cough, chest tightness, breathlessness, and activity limitation attributed to COPD symptoms [10]. The CAT total score indicates the symptom burden experienced by the patient; the total score ranges from 0 to 40, with higher scores (≥ 10) indicating a higher level of symptom burden than lower scores (0−9). While the GOLD strategic document provides direction on assessing symptoms and risk for patients with COPD, it is possible that other patient characteristics may provide further information and assist in predicting increased symptom burden for patients receiving inhaled therapy [6].

The objective of this multivariable analysis of a previously reported claims-linked, cross-sectional survey study [11] was to determine demographic, sociodemographic, and clinical characteristics that are predictors of higher symptom burden (as measured by the CAT), in an insured US population of patients with COPD receiving treatment with LAMA monotherapy.

Methods

Study Design

The study was a multivariable analysis of a previously reported claims-linked, cross-sectional survey of patients with COPD who were enrolled in commercial or Medicare Advantage (MA) insurance plans and prescribed LAMA monotherapy (study 205862 [HO-16-16642]) [11]. Medical and pharmacy claims and enrollment data from the Optum Research Database (ORD) were used to identify patients between October 1, 2015 and September 30, 2016. The ORD is a large, geographically diverse, US administrative claims database. In 2016, approximately 32.8 million individuals with commercial coverage and 3.2 million individuals with MA coverage were included in the ORD.

Patients who met the study inclusion criteria were recruited directly by mail, consented to the study, and returned a completed paper survey and/or 7-day daily diary. Survey data were collected using a modified Dillman method over 9 weeks from October to December 2016 [12]. Following return of the survey and/or diary, patients were paid $25, up to a maximum of $50 per patient. Prior to data collection, the study was approved by the New England Institutional Review Board (NEIRB #120160900; September 9, 2016). The study was conducted in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Patient Identification

Eligible patients were at least 40 years of age with ≥ 2 medical claims with COPD diagnosis codes (International Classification of Disease-10th Revision-Clinical Modification [ICD-10-CM] J40−J44 codes) in any position at least 30 days apart during the 12-month baseline period [11]. Participants were also required to be continuously enrolled in a commercial or MA health plan with both medical and pharmacy benefits during the baseline period and to have ≥ 2 pharmacy claims for a LAMA monotherapy in the most recent 6 months of the baseline period [11]. Patients were excluded if they had evidence of prior use of any ICS- or LABA-containing therapy (ICS, ICS/LABA, and LAMA/LABA) during the baseline period. Patients with evidence of diagnosis or treatment for lung cancer during the baseline period were excluded. To be included in this analysis, patients needed to self-report a physician diagnosis of COPD and current use of LAMA monotherapy, and were able to complete the study surveys in English.

Outcome Measures

Demographic, sociodemographic, and clinical characteristics were collected from patient-reported survey data and baseline claims data. Patient-reported symptom burden was measured using the CAT. Other PRO measures were also collected (mMRC, exacerbations of chronic pulmonary disease tool [EXACT], and medical outcomes short form health survey, 12 items, version 2 [SF-12v2]). COPD-related healthcare resource utilization (HCRU; assessed from the baseline period) was assessed from medical claims. HCRU was defined as COPD-related if the medical claim included an ICD-10-CM diagnosis code for COPD in any position.

Statistical Analysis

Patients who met all study inclusion and exclusion criteria and had complete, evaluable survey and diary data made up the analysis population. Statistical analyses were performed using SAS software (SAS Institute Inc., Cary, NC, USA, version 9.4) on a Unix platform. All study variables were analyzed descriptively. Dichotomous and polychotomous variables were presented as n (%) and continuous variables were presented as means, standard deviation (SD), and percentiles. Response rates were calculated and presented according to American Association for Public Opinion Research (AAPOR) Response Rate #4 recommendations [13].

Multivariable analysis using generalized linear regression modeling with normal distribution and identity link was conducted in order to assess the association between symptom burden and patient baseline characteristics. The dependent variable, CAT total score, was modeled as a continuous variable. The estimated impact on the CAT total score was assessed using patient-reported covariates (age, sex, marital status, educational attainment, urban/rural residence, smoking status, body mass index, and COPD diagnosis duration), and claims-based covariates (baseline Quan-Charlson comorbidity score [14], baseline depression, count of baseline COPD-related office visits [among patients with at least one office visit], and count of baseline COPD exacerbations). COPD exacerbations were defined as qualifying COPD hospitalization events, COPD ED events (with an antibiotic or oral corticosteroid prescription), or COPD ambulatory events (with an antibiotic or oral corticosteroid prescription). Covariates were selected based on descriptive results and clinical significance. Goodness of fit and multicollinearity statistics were assessed during the analysis, and no variables were removed due to endogeneity. Select demographic claims data supplemented missing self-reported information when possible in order to maintain sample size, and this applied to sex and age for three cases. In all analyses, a P value of < 0.05 was considered statistically significant. Variables were assessed on correlation with increasing or decreasing CAT scores, and were determined to be significant factors if they increased or decreased CAT scores ≥ 2 points, which has been determined to be the minimal difference that patients deem to be relevant.

Results

Study Population

As previously described, 2275 patients met the eligibility criteria and were invited to participate in the study, of whom 528 completed the survey. The response rate was 29.8%; [13] the final evaluable sample included 433 patients on LAMA monotherapy with matched claims, survey, and diary data [11]. Patient demographic, sociodemographic, and clinical characteristics are presented in Table 1. The majority of patients (370/433; 85.5%) had a CAT total score ≥ 10 (high CAT impact subgroup), with 169/433 (39.0%) having a score ≥ 21; 63/433 (14.5%) patients had a CAT score 0−9 (low CAT impact subgroup). The majority of patients were female (total 259/433, 59.8%; low CAT subgroup 28/63, 44.4%; high CAT subgroup 231/370, 62.4%) and were either current or former smokers (total 401/433, 92.6%; low CAT subgroup 56/63, 88.9%; high CAT subgroup 345/370, 93.2%). At baseline, mean (SD) Quan-Charlson score was 2.4 (1.8) in the low CAT subgroup and 2.2 (1.6) in the high CAT subgroup. During the 12-month baseline period, 13/63 (20.6%) patients in the low CAT subgroup and 141/370 (38.1%) patients in the high CAT subgroup had evidence of diagnosis and/or treatment for depression. COPD had an impact on the well-being of most patients as measured by the CAT. A high correlation was observed between the CAT and other PRO measures (Supplementary Table 1).

Table 1

Demographic, sociodemographic, and clinical characteristics

	Total(N = 433)	Low CAT impact (0−9)(n = 63)	High CAT impact(10−40)(n = 370)
Agea, mean (SD)	71.0 (9.4)	73.8 (7.0)	70.5 (9.7)
Femalea, n (%)	259 (59.8)	28 (44.4)	231 (62.4)
BMIa, kg/m2, mean (SD)	27.9 (7.3)	27.5 (5.0)	28.0 (7.6)
Marital statusa, n (%)
Married or living with a partner	193 (44.6)	38 (60.3)	155 (41.9)
Single, never married, separated, divorced, and/or widowed	240 (55.4)	25 (39.7)	215 (58.1)
Education levela, n (%)
High school or equivalent	247 (58.4)	34 (55.7)	213 (58.8)
College/graduate school	176 (41.6)	27 (44.3)	149 (41.2)
Urban/rural residencea, n (%)
Urban/city	149 (34.7)	28 (44.4)	121 (33.0)
Suburban	151 (35.1)	23 (36.5)	128 (34.9)
Rural	130 (30.2)	12 (19.1)	118 (32.2)
Smoking statusa, n (%)
Current smoker	122 (28.2)	9 (14.3)	113 (30.5)
Former smoker	279 (64.4)	47 (74.6)	232 (62.7)
Never smoked/lives with smoker	15 (3.5)	2 (3.2)	13 (3.5)
Never smoked/no household smoke	17 (3.9)	5 (7.9)	12 (3.2)
Time since COPD diagnosisa, n (%)
≤ 5 Years	226 (52.4)	36 (57.1)	190 (51.6)
> 5 Years	205 (47.6)	27 (42.9)	178 (48.4)
Quan-Charlson Comorbidity Scoreb, mean (SD)	2.2 (1.6)	2.4 (1.8)	2.2 (1.6)
COPD-related office visitsb,c, mean (SD)	3.7 (2.3)	3.2 (1.8)	3.7 (2.4)
COPD exacerbationsb,d, mean (SD)	1.9 (1.2)	1.6 (0.8)	2.0 (1.3)
Baseline depressionb,e, n (%)	154 (35.6)	13 (20.6)	141 (38.1)

Percentages were calculated based on respondents with available data except for missing values which were expressed as a percentage of the enrolled population (N = 433)

BMI body mass index, CAT COPD assessment test, COPD chronic obstructive pulmonary disease, ED emergency department, SD standard deviation

aSurvey-based

bClaim-based

cPatients with at least one office visit

dPatients with at least one COPD exacerbation, defined as a qualifying COPD hospitalization event, COPD ED event or COPD ambulatory event (with an antibiotic or oral corticosteroid prescription)

eEvidence of depression was assessed using both treatment and diagnosis codes from medical and pharmacy claims; diagnosis of and/or treatment for depression

Prediction of COPD Symptom Burden

The strongest predictors of an increase in CAT total score were being diagnosed with COPD for greater than 5 years (2.25 points, P = 0.003) and being a current smoker (2.22 points, P = 0.025) (Table 2). These two factors were related to a clinically meaningful increase in CAT scores. Other statistically significant predictors of increased COPD symptom burden included living in a rural location (increase of 1.99 points, P = 0.044), baseline count of COPD exacerbations (increase of 0.87 points, P = 0.006) and count of COPD-related office visits among patients with at least one office visit (increase of 0.43 points, P = 0.016). However, these increases did not reach a clinically meaningful increase of at least 2 points [15].

Table 2

Generalized linear regression model for predictors of increased CAT total score

Independent variable	Dependent variable—CAT total score
	Estimate	SE	Lower 95% CI	Upper 95% CI	P value
Intercept	12.23	2.20	7.92	16.54	< 0.001
Demographic/sociodemographic factors
Age (years)—survey-baseda—centeredb	– 0.04	0.06	– 0.16	0.07	0.449
Sex—survey-baseda (ref. female)
Male	– 0.34	0.84	– 1.99	1.30	0.681
Marital status (ref. married or living with a partner)
Single, never married, separated, divorced, and/or widowed	0.65	0.82	– 0.96	2.26	0.428
Highest level of education completed (ref. college/graduate school)
High school or equivalent	0.23	0.78	– 1.31	1.76	0.774
Urban/rural residence (ref. suburban)
Urban/city	– 0.18	0.90	– 1.95	1.58	0.838
Rural	1.99	0.99	0.05	3.92	0.044
Smoking status (ref. former smoker)
Current smoker	2.22	0.99	0.27	4.16	0.025
Never smokedc	2.05	1.48	– 0.86	4.96	0.166
Clinical characteristics
BMI	0.01	0.06	– 0.10	0.13	0.834
Time since COPD diagnosis (ref. ≤ 5 years)
> 5 years	2.25	0.77	0.74	3.76	0.003
Baselined Quan-Charlson comorbidity score	– 0.44	0.26	– 0.94	0.06	0.087
Number of COPD-related office visitse	0.43	0.18	0.08	0.78	0.016
Count of baselined COPD exacerbations (any)	0.87	0.32	0.25	1.49	0.006
Depressionf (ref. no depression)	2.97	0.86	1.29	4.65	< 0.001
Agea,bx depressionf interaction	– 0.31	0.08	– 0.47	– 0.14	< 0.001

Observations read = 387, observations used = 370

Generalized linear regression model, normal distribution with identity link

Pearson Chi-square = 19549.41, DF = 354. Park test: estimate = – 5.93

Only data for patients with a complete data set were included in the model

Where no reference category is specified, the variable was treated as continuous

Significant P values (< 0.05) are indicated in bold font

BMI body mass index, CI confidence interval, COPD chronic obstructive pulmonary disease, SE standard error

aPatient-reported age was missing for 2 patients, while patient-reported gender was missing for 1 patient; age and gender were ascertained for these patients using their claims enrollment records

bPatient-reported age was centered at 70 years

cNever smoking category included those that live with someone who smokes

d12 months immediately prior to the survey sample identification

eMedical claims with a primary diagnosis of COPD, among patients with at least one office visit

fBaseline claims-based diagnosis of and/or treatment for depression

Descriptive results indicated a statistically significant negative association between age and diagnosis of and/or treatment for depression; that is, depression tended to be less prevalent as age increased. An interaction term between age and depression was created to adjust for this correlation, with age centered at 70 years. The strength and statistical significance of covariates in the model with and without the interaction term were similar; all covariates that were statistically significant in the original model remained statistically significant when the age x depression interaction was included. The interaction of age and depression was a significant predictor of CAT total score (interaction term: – 0.31, P < 0.001, Table 2). CAT score had an inverse relationship with age among patients with depression, with older patients with depression having a lower CAT score than younger patients with depression. In contrast, the association between age and patient-reported symptom burden was not significant in those with no depression, indicating that presence of depression was related to the higher symptom burden and not related to age (Fig. 1).

Fig. 1

CAT total score by age, stratified by baseline claims-based diagnosis of and/or treatment for depression. Linear trend lines are based on scatterplots of CAT score x age among study population. CAT COPD assessment test, COPD chronic obstructive pulmonary disease

Discussion

In this multivariable analysis of a claims-linked survey study assessing symptom burden in patients with COPD receiving LAMA monotherapy, multiple patient-level factors that can influence symptom burden, as measured by CAT, were identified. In particular, patients with a long history of COPD diagnosis and who are current smokers were predicted to have a higher symptom burden as shown by an increase in CAT score of ≥ 2 points, which is the estimated minimal clinically important difference (MCID) [15]. This may be a reflection of disease progression and/or indicate that these patients may benefit from additional therapeutic intervention. It is interesting to note that baseline exacerbation counts were highly significant predictors of symptom burden; the effect did not meet the MCID threshold of ≥ 2 points. This may be due to factors that were not observed in this study, such as the time between the last exacerbation and patient survey. Similarly, other clinical or patient-level factors not assessed in this study may mediate the relationship between exacerbations and symptom burden. Other observational research has shown a stronger relationship between symptom burden and exacerbation rate [16], suggesting this is an important area for further research. Depression is an important comorbidity in patients with COPD and can have negative effects on mortality, rate of COPD exacerbation, length of hospital stay, quality of life (QoL), and functional status [17]. In this study, diagnosis of and/or treatment for depression was related to increased symptom burden when interacted with age (although it did not meet the estimated MCID of a CAT score ≥ 2 points). This association between CAT score and depression is consistent with previous studies [18], including prior evidence that suggests that age and high levels of symptoms are independent predictors of depression in patients with COPD, and are associated with a lower patient-reported health status [19].

The role of validated PROs in assessment of COPD has become increasingly important due to growing recognition of their value in reflecting the symptom burden and health status of individual patients [9, 20]. The mMRC dyspnea scale is a valid and reliable measure of breathlessness, relates well to other measures of health status, and can be predictive of mortality risk [6, 9, 21–23]. However, a more comprehensive assessment of symptoms, that goes beyond breathlessness, is now recommended [6]. The St George’s Respiratory Questionnaire (SGRQ) is the most widely documented tool for assessment for health status in COPD; however, with 50 questionnaire items, it is often considered to be too complex and burdensome for use in routine clinical practice [6, 20]. The CAT was developed as a more focused measure of symptom burden in COPD for routine clinical use; consisting of eight items, it is shorter and simpler to use than the SGRQ while providing a broader measure of symptom burden than the mMRC [10, 20, 24, 25]. The CAT has been found to be a reliable, appropriate, and responsive instrument for measuring symptom burden in patients with COPD [6, 10, 24, 26, 27], and has demonstrated good correlation with established QoL questionnaires, including the SGRQ, and other relevant measures of disease severity [28, 29]. This is consistent with published data, where a high level of correlation between measures of COPD symptom burden was noted, with > 70% of patients obtaining high scores on at least two PROs (Supplementary Table 1) [11].

The CAT can be used at a single point in time, is easy to use in clinical practice, and can improve patient−physician communication during routine clinical visits. In real-world studies, the CAT has demonstrated predictive value for future incidence of exacerbations [30] and all-cause mortality [31]. It is responsive to changes in health status following acute exacerbations or pulmonary rehabilitation [32], and it correlates with lung function impairment, exacerbation rates and number of comorbidities [33]. The development and use of the CAT in clinical trials, and continued use in real-world assessments, will ensure that key COPD concepts are reliably measured and that relevant treatment effects are being captured [20].

Standard of care for patients with COPD should include measures of symptom burden, such as the CAT, to evaluate patient outcomes [34]. Physicians should consider the use of instruments such as the CAT on a continuous basis as it has been shown to be responsive to recovery from an exacerbation [32], and to predict treatment failure [35]. It is important, however, for physicians to be aware of factors that may influence the CAT score both at diagnosis and on a continual basis [36]. As demonstrated in this study, factors such as time since COPD diagnosis, smoking status, rural versus urban location of residence, baseline counts of exacerbations, and number of office visits are important predictors of symptom burden as indicated by the observed increase in CAT score. The use of the CAT in this way may allow COPD treatment to be better targeted and patient management to be optimized, as well as potentially contributing to the amelioration of both the clinical and economic burden associated with COPD.

Claims-linked survey studies are associated with a number of limitations. The presence of a diagnosis code on a medical claim does not indicate conclusive evidence of the disease, as the diagnosis code may have been incorrectly coded or included as a rule-out criterion. Patients with a diagnosis of asthma were not excluded from the study and spirometry data were not available to confirm the COPD diagnoses. However, to help address these limitations, multiple pharmacy claims and diagnosis codes were required for inclusion. The study is also subject to limitations of survey data, including sampling, coverage, and measurement error. For example, treatment adherence was not measured in this study and the database does not provide information on whether a prescription was redeemed, which may have impacted outcomes. However, it is unlikely that this population has different patterns of adherence than other insured patient populations with COPD [37]. Finally, the study population was made up of patients with commercial health plan coverage and MA enrollees, and therefore the results of the study may not be reflective of uninsured populations, younger patients with COPD, or generalizable to populations outside the United States. For instance, the mean age of patients and proportion of females in our study was higher than typically reported for COPD populations [38], and the level of education was fairly low.

Conclusions

The results of this study demonstrate that there are multiple patient-level factors that can potentially influence symptom burden in patients with COPD receiving LAMA monotherapy, as measured by the CAT. Physicians should consider using tools/instruments such as the CAT to measure symptom impact as part of routine care for patients with COPD.

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 16 kb)