Two Worlds Collide: Unraveling the Role of the Immune System in BRAF-MEK Inhibitor Responses.

Although BRAF-MEK inhibition can enhance the immune recognition of melanoma cells, the mechanisms that underlie this remain poorly defined. In this issue of Cancer Discovery, Erkes and colleagues present new data showing that BRAF-MEK inhibition activates pyroptosis in melanoma cells through gasdermin E cleavage, leading to T-cell infiltration and improved therapy responses in vivo.See related article by Erkes et al., p. 254. ©2020 American Association for Cancer Research.