Literature DB >> 32024425

Probing Pedomorphy and Prolonged Lifespan in Naked Mole-Rats and Dwarf Mice.

Rochelle Buffenstein1, Kaitlyn N Lewis1, Patrick A Gibney1,2, Vikram Narayan1, Kelly M Grimes3, Megan Smith1, Tzuhua D Lin1, Holly M Brown-Borg4.   

Abstract

Pedomorphy, maintenance of juvenile traits throughout life, is most pronounced in extraordinarily long-lived naked mole-rats. Many of these traits (e.g., slow growth rates, low hormone levels, and delayed sexual maturity) are shared with spontaneously mutated, long-lived dwarf mice. Although some youthful traits likely evolved as adaptations to subterranean habitats (e.g., thermolability), the nature of these intrinsic pedomorphic features may also contribute to their prolonged youthfulness, longevity, and healthspan.

Entities:  

Keywords:  dwarf mouse; longevity; naked mole-rat; neoteny; protracted development; thyroid hormone

Mesh：

Year:  2020        PMID： 32024425     DOI： 10.1152/physiol.00032.2019

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  7 in total

Review 1.  Research-Relevant Conditions and Pathology of Laboratory Mice, Rats, Gerbils, Guinea Pigs, Hamsters, Naked Mole Rats, and Rabbits.

Authors:  Timothy K Cooper; David K Meyerholz; Amanda P Beck; Martha A Delaney; Alessandra Piersigilli; Teresa L Southard; Cory F Brayton
Journal:  ILAR J       Date:  2021-12-31       Impact factor: 1.521

2.  Fossorial adaptations in African mole-rats (Bathyergidae) and the unique appendicular phenotype of naked mole-rats.

Authors:  Germán Montoya-Sanhueza; Gabriel Šaffa; Radim Šumbera; Anusuya Chinsamy; Jennifer U M Jarvis; Nigel C Bennett
Journal:  Commun Biol       Date:  2022-06-01

3.  Cholesterol-rich naked mole-rat brain lipid membranes are susceptible to amyloid beta-induced damage in vitro.

Authors:  Daniel Frankel; Matthew Davies; Bharat Bhushan; Yavuz Kulaberoglu; Paulina Urriola-Munoz; Justine Bertrand-Michel; Melissa R Pergande; Andrew A Smith; Swapan Preet; Thomas J Park; Michele Vendruscolo; Kenneth S Rankin; Stephanie M Cologna; Janet R Kumita; Nicolas Cenac; Ewan St John Smith
Journal:  Aging (Albany NY)       Date:  2020-11-04       Impact factor: 5.682

Review 4.  The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.

Authors:  Rochelle Buffenstein; Vincent Amoroso; Blazej Andziak; Stanislav Avdieiev; Jorge Azpurua; Alison J Barker; Nigel C Bennett; Miguel A Brieño-Enríquez; Gary N Bronner; Clive Coen; Martha A Delaney; Christine M Dengler-Crish; Yael H Edrey; Chris G Faulkes; Daniel Frankel; Gerard Friedlander; Patrick A Gibney; Vera Gorbunova; Christopher Hine; Melissa M Holmes; Jennifer U M Jarvis; Yoshimi Kawamura; Nobuyuki Kutsukake; Cynthia Kenyon; Walid T Khaled; Takefumi Kikusui; Joseph Kissil; Samantha Lagestee; John Larson; Amanda Lauer; Leonid A Lavrenchenko; Angela Lee; Jonathan B Levitt; Gary R Lewin; Kaitlyn N Lewis Hardell; TzuHua D Lin; Matthew J Mason; Dan McCloskey; Mary McMahon; Kyoko Miura; Kazutaka Mogi; Vikram Narayan; Timothy P O'Connor; Kazuo Okanoya; M Justin O'Riain; Thomas J Park; Ned J Place; Katie Podshivalova; Matthew E Pamenter; Sonja J Pyott; Jane Reznick; J Graham Ruby; Adam B Salmon; Joseph Santos-Sacchi; Diana K Sarko; Andrei Seluanov; Alyssa Shepard; Megan Smith; Kenneth B Storey; Xiao Tian; Emily N Vice; Mélanie Viltard; Akiyuki Watarai; Ewa Wywial; Masanori Yamakawa; Elena D Zemlemerova; Michael Zions; Ewan St John Smith
Journal:  Biol Rev Camb Philos Soc       Date:  2021-09-03

Review 5.  Somatotropic Axis, Pace of Life and Aging.

Authors:  Andrzej Bartke
Journal:  Front Endocrinol (Lausanne)       Date:  2022-07-14       Impact factor: 6.055

6.  Auditory brainstem development of naked mole-rats (Heterocephalus glaber).

Authors:  Elizabeth A McCullagh; John Peacock; Alexandra Lucas; Shani Poleg; Nathaniel T Greene; Addison Gaut; Samantha Lagestee; Yalan Zhang; Leonard K Kaczmarek; Thomas J Park; Daniel J Tollin; Achim Klug
Journal:  Proc Biol Sci       Date:  2022-08-10       Impact factor: 5.530

7.  Promoting validation and cross-phylogenetic integration in model organism research.

Authors:  Keith C Cheng; Rebecca D Burdine; Mary E Dickinson; Stephen C Ekker; Alex Y Lin; K C Kent Lloyd; Cathleen M Lutz; Calum A MacRae; John H Morrison; David H O'Connor; John H Postlethwait; Crystal D Rogers; Susan Sanchez; Julie H Simpson; William S Talbot; Douglas C Wallace; Jill M Weimer; Hugo J Bellen
Journal:  Dis Model Mech       Date:  2022-09-20       Impact factor: 5.732
  7 in total

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