Erfan Ayubi1,2, Saeid Safiri3,4, Kamyar Mansori5,6. 1. Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. 2. Department of Community Medicine, School of Medicine, Zahedan University of Medical sciences, Zahedan, Iran. 3. Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran. 4. Department of Community Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. 5. Department of Biostatistics and Epidemiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. 6. Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Abstract
Purpose: The aim of this study was to investigate the effect of maternal smoking during pregnancy (MSDP) on the risk of bone fractures in offspring through a systematic review and meta-analysis. Methods: Electronic databases including PubMed, Web of Science and Scopus were systematically searched for relevant articles published up to July 2019. According to heterogeneity the pooled risk ratio (RR) and odds ratio (OR) and their corresponding 95% confidence interval (95% CI) were obtained by fixed or random effect model. Heterogeneity and quality of included studies were assessed by I-squared (I2) statistic and Newcastle-Ottawa scale, respectively. Sensitivity analyses were performed to test the effect of MSDP misclassification on the results. Results: After reviewing 842 search records, a total of 5 studies including 8746 mother-child pair were included in the meta-analysis. Pooling adjusted effect measures showed that MSDP was not associated with later risk of bone fractures in offspring (pooled RR=1.15, 95% CI: 0.84, 1.58, I2=66.8%, P=0.049). After adjusting for misclassification, MSDP may be associated with 27% increased risk of bone fracture (pooled OR=1.27, 95% CI: 1.00, 1.62, I2=0%, P=0.537). Conclusion: After adjusting for misclassification, the MSDP is associated with the increase risk of bone fractures among children whose mother smoke during pregnancy.
Purpose: The aim of this study was to investigate the effect of maternal smoking during pregnancy (MSDP) on the risk of bone fractures in offspring through a systematic review and meta-analysis. Methods: Electronic databases including PubMed, Web of Science and Scopus were systematically searched for relevant articles published up to July 2019. According to heterogeneity the pooled risk ratio (RR) and odds ratio (OR) and their corresponding 95% confidence interval (95% CI) were obtained by fixed or random effect model. Heterogeneity and quality of included studies were assessed by I-squared (I2) statistic and Newcastle-Ottawa scale, respectively. Sensitivity analyses were performed to test the effect of MSDP misclassification on the results. Results: After reviewing 842 search records, a total of 5 studies including 8746 mother-child pair were included in the meta-analysis. Pooling adjusted effect measures showed that MSDP was not associated with later risk of bone fractures in offspring (pooled RR=1.15, 95% CI: 0.84, 1.58, I2=66.8%, P=0.049). After adjusting for misclassification, MSDP may be associated with 27% increased risk of bone fracture (pooled OR=1.27, 95% CI: 1.00, 1.62, I2=0%, P=0.537). Conclusion: After adjusting for misclassification, the MSDP is associated with the increase risk of bone fractures among children whose mother smoke during pregnancy.
Entities:
Keywords:
Bone fractures; Maternal smoking; Meta analyses; Misclassification; Pregnancy
Authors: Won Seok Lee; Kyung Suk Lee; Eun Kyo Ha; Ju Hee Kim; So Min Shim; Seung Won Lee; Man Yong Han Journal: Sci Rep Date: 2022-06-17 Impact factor: 4.996