Literature DB >> 32021047

Tranexamic acid is toxic on human chondrocytes, in vitro.

Benjamin Jacob1, Nadja Kloss1, Sabrina Böhle1, Julia Kirschberg1, Timo Zippelius1, Markus Heinecke1, Georg Matziolis1, Eric Röhner1.   

Abstract

The aim of this study was to examine toxic effects of tranexamic acid (TXA) on the viability of human chondrocytes. Our hypothesis was that TXA damages human chondrocytes. Chondrocytes were cultured from donated human knee joints. TXA was added to these cultures. Toxicity were analyzed by using LDH und XTT Elisa assays, light microscopy and fluorescence microscopy. The results show that TXA damages human chondrocytes in vitro. We cannot recommend the use of TXA in hemiarthroplasty of the hip or unicompartmental knee arthroplasty in higher concentrations.
© 2019 Professor P K Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cell damage; Human chondrocytes; Toxicity; Tranexamic acid; Viability

Year:  2019        PMID： 32021047      PMCID： PMC6994788          DOI： 10.1016/j.jor.2019.12.008

Source DB:  PubMed          Journal:  J Orthop        ISSN： 0972-978X


  20 in total

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Authors:  A Sassoon; D Nam; R Jackups; S R Johnson; R M Nunley; R L Barrack
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4.  Multiple boluses of intravenous tranexamic acid to reduce hidden blood loss and the inflammatory response following enhanced-recovery primary total hip arthroplasty: a randomised clinical trial.

Authors:  J Xie; Q Hu; J Ma; Q Huang; F Pei
Journal:  Bone Joint J       Date:  2017-11       Impact factor: 5.082

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Review 6.  Topical tranexamic acid in total knee replacement: a systematic review and meta-analysis.

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Journal:  Knee       Date:  2013-06-28       Impact factor: 2.199

7.  Effects of Tranexamic Acid Cytotoxicity on In Vitro Chondrocytes.

Authors:  John R Tuttle; Peter R Feltman; Scott A Ritterman; Michael G Ehrlich
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8.  The combined effect of administration of intravenous and topical tranexamic acid on blood loss and transfusion rate in total knee arthroplasty: Combined tranexamic acid for TKA.

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Journal:  Bone Joint Res       Date:  2019-02-02       Impact factor: 5.853
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Review 2.  Toxicity of tranexamic acid (TXA) to intra-articular tissue in orthopaedic surgery: a scoping review.

Authors:  Scott M Bolam; Arama O'Regan-Brown; A Paul Monk; David S Musson; Jillian Cornish; Jacob T Munro
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2020-08-29       Impact factor: 4.342

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Review 6.  Peri-articular administration of tranexamic acid is an alternative route in total knee arthroplasty: a systematic review and meta-analysis.

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