Stefan De Wachter1, Donald Vaganee2, Thomas M Kessler3. 1. Department of Urology, Antwerp Academic Hospital, Edegem, Belgium; Department of Urology, Faculty of Medicine and Health Sciences, Antwerp University, Wilrijk, Belgium. Electronic address: stefan.dewachter@uantwerpen.be. 2. Department of Urology, Antwerp Academic Hospital, Edegem, Belgium; Department of Urology, Faculty of Medicine and Health Sciences, Antwerp University, Wilrijk, Belgium. 3. Department of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
Abstract
Although the mechanism of action of sacral neuromodulation (SNM) is still not fully elucidated, it seems to involve modulation of spinal cord reflexes and brain networks by peripheral afferents according to findings from neurophysiology, electroencephalography, positron emission tomography, and magnetic resonance imaging studies. Moreover, motor effects mediated via efferents on direct stimulation cannot be fully excluded. In this mini-review, we summarize current knowledge on the mechanism of action of SNM. PATIENT SUMMARY: We reviewed the literature on the mechanism of action of sacral neuromodulation, in which electrical stimulation is applied to the nerves that regulate bladder activity. The mechanism seems to involve modulation of spinal cord reflexes and brain networks by peripheral sensory and possibly motor neurons.
Although the mechanism of action of sacral neuromodulation (SNM) is still not fully elucidated, it seems to involve modulation of spinal cord reflexes and brain networks by peripheral afferents according to findings from neurophysiology, electroencephalography, positron emission tomography, and magnetic resonance imaging studies. Moreover, motor effects mediated via efferents on direct stimulation cannot be fully excluded. In this mini-review, we summarize current knowledge on the mechanism of action of SNM. PATIENT SUMMARY: We reviewed the literature on the mechanism of action of sacral neuromodulation, in which electrical stimulation is applied to the nerves that regulate bladder activity. The mechanism seems to involve modulation of spinal cord reflexes and brain networks by peripheral sensory and possibly motor neurons.
Authors: Margarita Martínez-Gómez; Mario I Romero-Ortega; Ana G Hernandez-Reynoso; Dora L Corona-Quintanilla; Kenia López-García; Ana A Horbovetz; Francisco Castelán; Philippe Zimmern Journal: Sci Rep Date: 2021-05-19 Impact factor: 4.379
Authors: Christopher M Hornung; Ranveer Vasdev; Kate A Hanson; Rachael Gotlieb; Cynthia S Fok; John Fischer; Nissrine A Nakib; Dwight E Nelson Journal: Int Neurourol J Date: 2022-09-30 Impact factor: 3.038