Abdulrahman F AlBloushi1, Abdulsalam M Dheyab1, Nayef F Al-Swaina1, Majed Al-Obailan1, Abdul-Kader Daif2, Ahmed M Abu El-Asrar1,3. 1. Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. 2. Division of Neurology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia. 3. Dr. Nasser Al-Rashid Research Chair in Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Abstract
PURPOSE: To describe the clinical findings and outcomes in patients who presented with uveitis associated with multiple sclerosis. METHODS: Retrospective review of 20 patients (38 eyes). RESULTS: The most frequent ocular finding was multifocal elongated retinal perivenous "sheathing" with focal vascular leakage on fundus fluorescein angiography in 29 eyes followed by vitreous snowballs and debris in 26 eyes, anterior chamber inflammation in 15 eyes, mutton-fat keratic precipitates in 14 eyes, posterior synechiae in 13 eyes, cystoid macular edema in 9 eyes, iris nodules in 4 eyes, and optic neuritis in 3 eyes. Patients with cystoid macular edema were treated successfully with systemic corticosteroids combined with mycophenolate mofetil. Ocular complications were cataract in 6 eyes, glaucoma in 2 eyes and vitreous hemorrhage in 1 eye. CONCLUSIONS: Multifocal elongated retinal perivenous "sheathing" with focal vascular leakage on fundus fluorescein angiography is the most frequent finding in uveitis associated with multiple sclerosis.
PURPOSE: To describe the clinical findings and outcomes in patients who presented with uveitis associated with multiple sclerosis. METHODS: Retrospective review of 20 patients (38 eyes). RESULTS: The most frequent ocular finding was multifocal elongated retinal perivenous "sheathing" with focal vascular leakage on fundus fluorescein angiography in 29 eyes followed by vitreous snowballs and debris in 26 eyes, anterior chamber inflammation in 15 eyes, mutton-fat keratic precipitates in 14 eyes, posterior synechiae in 13 eyes, cystoid macular edema in 9 eyes, iris nodules in 4 eyes, and optic neuritis in 3 eyes. Patients with cystoid macular edema were treated successfully with systemic corticosteroids combined with mycophenolate mofetil. Ocular complications were cataract in 6 eyes, glaucoma in 2 eyes and vitreous hemorrhage in 1 eye. CONCLUSIONS: Multifocal elongated retinal perivenous "sheathing" with focal vascular leakage on fundus fluorescein angiography is the most frequent finding in uveitis associated with multiple sclerosis.