Literature DB >> 3201756

Crystallization and preliminary X-ray analysis of type B influenza virus neuraminidase complexed with antibody Fab fragments.

W G Laver1, M Luo, P J Bossart, Y S Babu, C Smith, M A Accavitti, P A Tulloch, G M Air.   

Abstract

Fab fragments from four different monoclonal antibodies have been complexed with influenza B virus neuraminidase (B/Lee/40) and the complexes have been crystallized. Three of the complex crystals are, so far, not suitable for X-ray diffraction studies, but the fourth (B/Lee/40 NA-B1Fab) forms large crystals which diffract X-rays to 3.0 A resolution. The crystals have a space group of F432, a = 441.21 A. Vm calculations show that the asymmetric unit contains two monomeric complexes.

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Year:  1988        PMID： 3201756

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  3 in total

1.  Mechanism of antigenic variation in an individual epitope on influenza virus N9 neuraminidase.

Authors:  G M Air; W G Laver; R G Webster
Journal:  J Virol       Date:  1990-12       Impact factor: 5.103

2.  Evolutionary changes in influenza B are not primarily governed by antibody selection.

Authors:  G M Air; A J Gibbs; W G Laver; R G Webster
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

3.  Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes.

Authors:  Teddy John Wohlbold; Kira A Podolsky; Veronika Chromikova; Ericka Kirkpatrick; Veronica Falconieri; Philip Meade; Fatima Amanat; Jessica Tan; Benjamin R tenOever; Gene S Tan; Sriram Subramaniam; Peter Palese; Florian Krammer
Journal:  Nat Microbiol       Date:  2017-08-21       Impact factor: 17.745
  3 in total

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