Aslinur Sircan-Kucuksayan1, Neslihan Yaprak2, Alper Tunga Derin3, İrem Hicran Ozbudak4, Murat Turhan3, Murat Canpolat5. 1. Department of Biophysics, School Of Medicine, Alaaddin Keykubat University, Alanya, Antalya, Turkey. 2. Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Akdeniz University, Dumlupınar Boulevard 07058 Campus, Antalya, Turkey. neslihanyaprak@yahoo.com. 3. Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Akdeniz University, Dumlupınar Boulevard 07058 Campus, Antalya, Turkey. 4. Department of Pathology, School of Medicine, Akdeniz University, Antalya, Turkey. 5. Department of Biophysics, School of Medicine, Akdeniz University, Antalya, Turkey.
Abstract
PURPOSE: In the present study, we investigated the potential application of elastic light single-scattering spectroscopy (ELSSS) as a noninvasive, adjunctive tool to differentiate between malignant and benign oral lesions in vivo. METHODS: ELSSS spectra were acquired from 52 oral lesions of 47 patients prior to surgical biopsy using a single optical fiber probe. The sign of the spectral slope was used as a diagnostic parameter and was compared to the histopathology findings to obtain sensitivity and specificity of the ELSSS system in differentiating between benign and malignant tissues. RESULTS: The sign of the spectral slope was positive for the benign tissues and negative for the malignant tissues. Nine malignant lesions and one high-grade dysplasia were correctly classified as cancerous. Six out of the ten low-grade dysplasia were correctly classified as cancerous, and four of them were misclassified as benign. Thirty benign lesions were correctly classified as benign, and two were misclassified as malignant. Our results indicate that the sign of the spectral slope enables the differentiation between malignant and benign oral lesions with a sensitivity of 80% and specificity of 94%. CONCLUSIONS: ELSSS has the potential to be developed as an adjunctive screening tool in the noninvasive evaluation of oral lesions in vivo. This new diagnostic system may reduce the number of unnecessary biopsies.
PURPOSE: In the present study, we investigated the potential application of elastic light single-scattering spectroscopy (ELSSS) as a noninvasive, adjunctive tool to differentiate between malignant and benign oral lesions in vivo. METHODS: ELSSS spectra were acquired from 52 oral lesions of 47 patients prior to surgical biopsy using a single optical fiber probe. The sign of the spectral slope was used as a diagnostic parameter and was compared to the histopathology findings to obtain sensitivity and specificity of the ELSSS system in differentiating between benign and malignant tissues. RESULTS: The sign of the spectral slope was positive for the benign tissues and negative for the malignant tissues. Nine malignant lesions and one high-grade dysplasia were correctly classified as cancerous. Six out of the ten low-grade dysplasia were correctly classified as cancerous, and four of them were misclassified as benign. Thirty benign lesions were correctly classified as benign, and two were misclassified as malignant. Our results indicate that the sign of the spectral slope enables the differentiation between malignant and benign oral lesions with a sensitivity of 80% and specificity of 94%. CONCLUSIONS: ELSSS has the potential to be developed as an adjunctive screening tool in the noninvasive evaluation of oral lesions in vivo. This new diagnostic system may reduce the number of unnecessary biopsies.
Authors: L Moneghini; V Sangiorgio; D Tosi; G Colletti; F Melchiorre; V Baraldini; D Graziani; R M Alfano; G Vercellio; G Bulfamante Journal: Pathologica Date: 2017-03
Authors: Jean-Philippe Foy; Chloé Bertolus; William N William; Pierre Saintigny Journal: Otolaryngol Clin North Am Date: 2013-05-25 Impact factor: 3.346