Model-based robust suppression of epileptic seizures without sensory measurements.

Uncontrolled seizures may lead to irreversible damages in the brain and various limitations in the patient's life. There exist experimental studies to stabilize the patient seizures. However, the experimental setups have many sensory devices to measure the dynamics of the brain cortex. These equipments prevent to produce small portable stabilizers for patients in everyday life. Recently, a comprehensive cortex model is introduced to apply model-based observers and controllers. However, this cortex model can be uncertain and have time-varying parameters. Therefore, in this paper, a robust Takagi-Sugeno (TS) controller and observer are designed to suppress the epileptic seizures without sensory measurements. The unavailable sensory measurements are provided by the designed nonlinear observer. The exponential convergence of the observer and controller is satisfied by the feedback parameter design using linear matrix inequalities. In addition, TS fuzzy observer-controller design has been compared with the conventional PID method in terms of control performance and design problem. The numerical computations show that the epileptic seizures are more effectively suppressed by the TS fuzzy observer-based controller under uncertain membrane potential dynamics. © Springer Nature B.V. 2019.