Daniela Pierscianek1,2, Yahya Ahmadipour3,2, Anna Michel3,2, Mehdi Chihi3,2, Marvin Darkwah Oppong3,2, Sied Kebir2,4, Martin Glas2,4, Martin Stuschke2,5, Ulrich Sure3,2, Ramazan Jabbarli3,2. 1. Department of Neurosurgery, University Hospital Essen, Essen, Germany daniela.pierscianek@uk-essen.de. 2. German Cancer Consortium, Partner Site, University Hospital Essen, Essen, Germany. 3. Department of Neurosurgery, University Hospital Essen, Essen, Germany. 4. Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, Essen, Germany. 5. Department of Radiotherapy, University Hospital Essen, Essen, Germany.
Abstract
BACKGROUND: Glioblastoma (GBM) is the most common malignant brain tumor in adults and still carries a dismal prognosis. As several studies detected a connection between inflammation and GBM prognosis, we sought to explore possible associations between routinely investigated inflammatory parameters and GBM outcome. PATIENTS AND METHODS: Patients treated for GBM at our Institution between 2004 and 2014 were included. White blood cell count (WBC), C-reactive protein (CRP) and the ratio of platelets and WBC (Plt/WBC) were evaluated preoperatively. Medical records were reviewed for clinical parameters (age, sex, preoperative clinical condition, genetic alterations). Study endpoints were overall (OS) and 1- and 2-year survival. RESULTS: In the final cohort consisting of 565 individuals with GBM, univariate analysis showed significant associations for WBC, CRP and Plt/WBC ratio with OS. Kaplan-Meier survival plot confirmed significantly poorer OS in patients with WBC>12/nl and with CRP≥2.9 mg/dl. In multivariate analysis, a WBC of >12/nl was an independent prognostic factor for all three outcome parameters and CRP≥2.9 mg/dl for OS and 1-year survival. CONCLUSION: Preoperative WBC and CRP values were confirmed as independent predictors of GBM outcome. This emphasizes the need for further evaluation of the role of inflammation in the prognosis of GBM. Copyright
BACKGROUND:Glioblastoma (GBM) is the most common malignant brain tumor in adults and still carries a dismal prognosis. As several studies detected a connection between inflammation and GBM prognosis, we sought to explore possible associations between routinely investigated inflammatory parameters and GBM outcome. PATIENTS AND METHODS: Patients treated for GBM at our Institution between 2004 and 2014 were included. White blood cell count (WBC), C-reactive protein (CRP) and the ratio of platelets and WBC (Plt/WBC) were evaluated preoperatively. Medical records were reviewed for clinical parameters (age, sex, preoperative clinical condition, genetic alterations). Study endpoints were overall (OS) and 1- and 2-year survival. RESULTS: In the final cohort consisting of 565 individuals with GBM, univariate analysis showed significant associations for WBC, CRP and Plt/WBC ratio with OS. Kaplan-Meier survival plot confirmed significantly poorer OS in patients with WBC>12/nl and with CRP≥2.9 mg/dl. In multivariate analysis, a WBC of >12/nl was an independent prognostic factor for all three outcome parameters and CRP≥2.9 mg/dl for OS and 1-year survival. CONCLUSION: Preoperative WBC and CRP values were confirmed as independent predictors of GBM outcome. This emphasizes the need for further evaluation of the role of inflammation in the prognosis of GBM. Copyright
Authors: Matthias Schneider; Niklas Schäfer; Christian Bode; Valeri Borger; Lars Eichhorn; Frank A Giordano; Erdem Güresir; Muriel Heimann; Yon-Dschun Ko; Felix Lehmann; Anna-Laura Potthoff; Alexander Radbruch; Christina Schaub; Katjana S Schwab; Johannes Weller; Hartmut Vatter; Ulrich Herrlinger; Jennifer Landsberg; Patrick Schuss Journal: J Clin Med Date: 2021-02-07 Impact factor: 4.241
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Authors: Killen H Briones-Claudett; Mónica H Briones-Claudett; Freddy Villacrés Garcia; Camilo Ortega Almeida; Andrea Escudero-Requena; Jaime Benítez Solís; Killen H Briones Zamora; Diana C Briones Márquez; Michelle Grunauer Journal: Am J Case Rep Date: 2020-07-31