M Lester1, A L O'Kell2. 1. Small Animal Hospital, College of Veterinary Medicine, University of Florida, Gainesville, Florida, 32608, USA. 2. Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, 32608, USA.
Abstract
OBJECTIVES: To quantify anti-insulin antibodies in diabetic dogs treated with recombinant human insulin and to determine if insulin dosage or duration of treatment differed between anti-insulin antibody-positive and -negative diabetic dogs. MATERIALS AND METHODS: Descriptive preliminary study using serum from 24 client-owned diabetic dogs treated for a minimum of 2 weeks with recombinant human insulin, and 24 client-owned healthy control dogs without diabetes. Sera were analysed by radioimmunoassay for anti-insulin antibodies. The proportion of antibody positive dogs was compared between groups by Fisher's exact test. RESULTS: Four diabetic (16.6%) and no control dogs were anti-insulin antibody positive. CLINICAL SIGNIFICANCE: These results indicate that treatment with recombinant human insulin may induce anti-insulin antibodies in dogs, although this finding needs to be re-investigated in a larger study to investigate the impact of anti-insulin antibodies on glycaemic control.
OBJECTIVES: To quantify anti-insulin antibodies in diabeticdogs treated with recombinant humaninsulin and to determine if insulin dosage or duration of treatment differed between anti-insulin antibody-positive and -negative diabeticdogs. MATERIALS AND METHODS: Descriptive preliminary study using serum from 24 client-owned diabeticdogs treated for a minimum of 2 weeks with recombinant humaninsulin, and 24 client-owned healthy control dogs without diabetes. Sera were analysed by radioimmunoassay for anti-insulin antibodies. The proportion of antibody positive dogs was compared between groups by Fisher's exact test. RESULTS: Four diabetic (16.6%) and no control dogs were anti-insulin antibody positive. CLINICAL SIGNIFICANCE: These results indicate that treatment with recombinant humaninsulin may induce anti-insulin antibodies in dogs, although this finding needs to be re-investigated in a larger study to investigate the impact of anti-insulin antibodies on glycaemic control.
Authors: Sean E Hulsebosch; Jully Pires; Michael J Bannasch; Thomas Lancaster; Andrea Delpero; Ramya Ragupathy; Sylaja Murikipudi; Todd Zion; Chen Gilor Journal: J Vet Intern Med Date: 2022-05-27 Impact factor: 3.175