GOALS: We investigated the long-term efficacy and safety of fecal microbiota transplant (FMT) for the treatment of recurrent Clostridioides difficile infection (rCDI). BACKGROUND: FMT has emerged as a promising therapy for patients with rCDI unresponsive to standard medical therapy, though long-term efficacy and safety data are scarce. MATERIALS AND METHODS: A multicenter retrospective study was performed on patients treated with FMT for rCDI with ≥6 months of clinical follow-up post-FMT. Patients were contacted to document sustained efficacy, potential adverse events, and antibiotic exposure. The electronic medical record was reviewed to confirm patient-reported outcomes and obtain additional data. The primary outcome was sustained cure, as defined by the absence of Clostridioides difficile infection (CDI) at any timepoint after FMT. RESULTS: Of 528 patients treated, 207 were successfully contacted. The mean follow-up post-FMT was 34 (range: 6 to 84) months. One hundred fifty-seven patients (75.8%) reported sustained cure at the time of follow-up. One hundred patients (48%) reported the use of antibiotics for non-CDI indications post-FMT, of whom 11 (11%) had experienced CDI post-FMT. Fifty-two of the original 528 patients (9.8%) treated with FMT had died at the time of follow-up contact; none were felt attributable to the procedure. New medical conditions or diagnoses post-FMT were reported in 105 patients (50.5%). Fifteen reported improvement post-FMT in previously diagnosed medical conditions. CONCLUSIONS: In this largest and longest study to date on efficacy and safety after FMT for treatment of rCDI, we found that the majority of patients experienced long-term cure. Although a number of new conditions developed post-FMT, there was no clustering of diseases associated with dysbiosis.
GOALS: We investigated the long-term efficacy and safety of fecal microbiota transplant (FMT) for the treatment of recurrent Clostridioides difficile infection (rCDI). BACKGROUND: FMT has emerged as a promising therapy for patients with rCDI unresponsive to standard medical therapy, though long-term efficacy and safety data are scarce. MATERIALS AND METHODS: A multicenter retrospective study was performed on patients treated with FMT for rCDI with ≥6 months of clinical follow-up post-FMT. Patients were contacted to document sustained efficacy, potential adverse events, and antibiotic exposure. The electronic medical record was reviewed to confirm patient-reported outcomes and obtain additional data. The primary outcome was sustained cure, as defined by the absence of Clostridioides difficile infection (CDI) at any timepoint after FMT. RESULTS: Of 528 patients treated, 207 were successfully contacted. The mean follow-up post-FMT was 34 (range: 6 to 84) months. One hundred fifty-seven patients (75.8%) reported sustained cure at the time of follow-up. One hundred patients (48%) reported the use of antibiotics for non-CDI indications post-FMT, of whom 11 (11%) had experienced CDI post-FMT. Fifty-two of the original 528 patients (9.8%) treated with FMT had died at the time of follow-up contact; none were felt attributable to the procedure. New medical conditions or diagnoses post-FMT were reported in 105 patients (50.5%). Fifteen reported improvement post-FMT in previously diagnosed medical conditions. CONCLUSIONS: In this largest and longest study to date on efficacy and safety after FMT for treatment of rCDI, we found that the majority of patients experienced long-term cure. Although a number of new conditions developed post-FMT, there was no clustering of diseases associated with dysbiosis.
Authors: O Lima; A Sousa; A Filgueira; M Carmen González-Novoa; Celina Domínguez-López; M Ávila-Nuñez; M Represa; P Rubiñán; L Martínez-Lamas; Sonia Pérez-Castro; M Rubianes; M T Pérez-Rodríguez Journal: Eur J Clin Microbiol Infect Dis Date: 2022-10-07 Impact factor: 5.103
Authors: Elisabeth M Terveer; Karuna Ew Vendrik; Rogier E Ooijevaar; Emilie van Lingen; Eline Boeije-Koppenol; Els van Nood; Abraham Goorhuis; Martijn P Bauer; Yvette H van Beurden; Marcel Gw Dijkgraaf; Chris Jj Mulder; Christina Mje Vandenbroucke-Grauls; Jos Fml Seegers; Joffrey van Prehn; Hein W Verspaget; Ed J Kuijper; Josbert J Keller Journal: United European Gastroenterol J Date: 2020-09-29 Impact factor: 4.623
Authors: R E Ooijevaar; E van Nood; A Goorhuis; E M Terveer; J van Prehn; H W Verspaget; Y H van Beurden; M G W Dijkgraaf; J J Keller Journal: Microorganisms Date: 2021-03-06
Authors: Josbert J Keller; Rogier E Ooijevaar; Christian L Hvas; Elisabeth M Terveer; Simone C Lieberknecht; Christoph Högenauer; Perttu Arkkila; Harry Sokol; Oleksiy Gridnyev; Francis Mégraud; Patrizia K Kump; Radislav Nakov; Simon D Goldenberg; Reetta Satokari; Sergiy Tkatch; Maurizio Sanguinetti; Giovanni Cammarota; Andrey Dorofeev; Olena Gubska; Gianluca Laniro; Eero Mattila; Ramesh P Arasaradnam; Shiv K Sarin; Ajit Sood; Lorenza Putignani; Laurent Alric; Simon M D Baunwall; Juozas Kupcinskas; Alexander Link; Abraham G Goorhuis; Hein W Verspaget; Cyriel Ponsioen; Georgina L Hold; Herbert Tilg; Zain Kassam; Ed J Kuijper; Antonio Gasbarrini; Chris J J Mulder; Horace R T Williams; Maria J G T Vehreschild Journal: United European Gastroenterol J Date: 2021-03-09 Impact factor: 4.623