Aulikki Kononoff1, Pia Elfving1, Pirkko Pussinen2, Sohvi Hörkkö3, Hannu Kautiainen4,5, Leena Arstila1,6, Leena Laasonen7, Elina Savolainen1, Helena Niinisalo8,9, Jarno Rutanen1, Olga Marjoniemi1, Mari Hämäläinen10, Katriina Vuolteenaho10, Eeva Moilanen10, Oili Kaipiainen-Seppänen1. 1. Department of Medicine, Kuopio University Hospital, Kuopio, Finland. 2. Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland. 3. Institute of Diagnostics, Medical Microbiology and Immunology, Research Unit of Biomedicine, Oulu University Hospital, University of Oulu and Medical Research Center and Nordlab Oulu, Oulu, Finland. 4. Unit of Primary Health Care, Kuopio University Hospital, Kuopio, Finland. 5. Unit of Family Practice, Central Finland Central Hospital, Jyväskylä, Finland. 6. Department of Medicine, Iisalmi Hospital. 7. Helsinki Medical Imaging Center, Helsinki University Hospital, Helsinki, Finland. 8. Department of Medicine, Varkaus Hospital. 9. Outpatient Clinic, Suonenjoki Health Center. 10. School of Medicine, The Immunopharmacology Research Group, Tampere University Hospital, University of Tampere, Tampere, Finland.
Abstract
Objective: We investigated lipid concentrations, particle sizes and antibodies binding to periodontal bacteria Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis and to malondialdehyde-acetaldehyde (MAA) modified low-density lipoprotein in immunoglobulin (Ig) class A, G and M among patients with newly diagnosed rheumatoid arthritis (RA) in a population-based cohort. Methods: Concentrations and sizes of lipoprotein particles analysed by proton nuclear magnetic resonance spectroscopy and antibody levels to MAA modified low-density lipoprotein were studied at baseline and after one-year of follow-up. Serum Ig A and G class antibodies to periodontal bacteria were determined at baseline. Results: Sixty-three patients were divided into tertiles according to disease activity by disease activity score with 28 joint count and erythrocyte sedimentation rate (ESR) (<3.9, 3.9-4.7, >4.7). Small low-density lipoprotein concentration was lowest in the tertile with the highest disease activity. In high-density lipoprotein, the concentrations of total, medium and small particles decreased with disease activity. The particle size in low-density lipoprotein associated with disease activity and the presence of antibodies to P. gingivalis. Ig G and M antibodies to MAA modified low-density lipoprotein correlated with disease activity. Inflammation associated changes faded by one year.Conclusions: Drug naive RA patients had proatherogenic changes in lipid profiles, but they were reversible, when inflammation diminished.Key messagesPatients with drug naive rheumatoid arthritis showed proatherogenic lipid profiles.Reversible changes in lipid profiles can be achieved as response to inflammation suppression.Active therapy aimed at remission is essential in all patients with rheumatoid arthritis.
Objective: We investigated lipid concentrations, particle sizes and antibodies binding to periodontal bacteria Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis and to malondialdehyde-acetaldehyde (MAA) modified low-density lipoprotein in immunoglobulin (Ig) class A, G and M among patients with newly diagnosed rheumatoid arthritis (RA) in a population-based cohort. Methods: Concentrations and sizes of lipoprotein particles analysed by proton nuclear magnetic resonance spectroscopy and antibody levels to MAA modified low-density lipoprotein were studied at baseline and after one-year of follow-up. Serum Ig A and G class antibodies to periodontal bacteria were determined at baseline. Results: Sixty-three patients were divided into tertiles according to disease activity by disease activity score with 28 joint count and erythrocyte sedimentation rate (ESR) (<3.9, 3.9-4.7, >4.7). Small low-density lipoprotein concentration was lowest in the tertile with the highest disease activity. In high-density lipoprotein, the concentrations of total, medium and small particles decreased with disease activity. The particle size in low-density lipoprotein associated with disease activity and the presence of antibodies to P. gingivalis. Ig G and M antibodies to MAA modified low-density lipoprotein correlated with disease activity. Inflammation associated changes faded by one year.Conclusions: Drug naive RApatients had proatherogenic changes in lipid profiles, but they were reversible, when inflammation diminished.Key messagesPatients with drug naive rheumatoid arthritis showed proatherogenic lipid profiles.Reversible changes in lipid profiles can be achieved as response to inflammation suppression.Active therapy aimed at remission is essential in all patients with rheumatoid arthritis.
Authors: Pasi Soininen; Antti J Kangas; Peter Würtz; Taru Tukiainen; Tuulia Tynkkynen; Reino Laatikainen; Marjo-Riitta Järvelin; Mika Kähönen; Terho Lehtimäki; Jorma Viikari; Olli T Raitakari; Markku J Savolainen; Mika Ala-Korpela Journal: Analyst Date: 2009-07-30 Impact factor: 4.616
Authors: J T Cvetkovic; S Wållberg-Jonsson; E Ahmed; S Rantapää-Dahlqvist; A K Lefvert Journal: Rheumatology (Oxford) Date: 2002-09 Impact factor: 7.580
Authors: T Bengtsson; H Karlsson; P Gunnarsson; C Skoglund; C Elison; P Leanderson; M Lindahl Journal: J Intern Med Date: 2008-02-01 Impact factor: 8.989