| Literature DB >> 32009638 |
Di Liu1, Xizhu Xu2, Yuejin Li2, Jie Zhang1, Xiaoyu Zhang1, Qihuan Li1, Haifeng Hou2, Dong Li2, Wei Wang3, Youxin Wang4.
Abstract
Glycomics is a new subspecialty in omics system research that offers significant potential in discovering next-generation biomarkers for disease susceptibility, drug target discovery, and precision medicine. Alternative IgG N-glycans have been reported in several common chronic diseases and suggested to have great potential in clinical applications (i.e., biomarkers for diagnosis and prediction of diseases). IgG N-glycans are widely characterized using the method of hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC). UPLC is a stable detection technology with good reproducibility and high relative quantitative accuracy. In addition, the structure of IgG N-glycan is clearly separated, and glycan composition and relative abundance in plasma are characterized.Entities:
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Year: 2020 PMID： 32009638 DOI： 10.3791/60104
Source DB: PubMed Journal: J Vis Exp ISSN： 1940-087X Impact factor: 1.355