| Literature DB >> 32008963 |
P Chen1, J Liu1, M Zeng1, H Sang2.
Abstract
Aspergillus infections are increasingly recognized as a global health problem because of limited antifungal drugs and occurrence of azole resistance worldwide. More cyp51-mediated and non-cyp51-mediated mechanisms of azole resistance have been identified in clinical and laboratory studies in recent years with applications of molecular biotechnology including next-generation sequencing, reverse genetics and so on. In this review, current research on the molecular mechanisms of azole resistance in A. fumigatus were presented and summarized and meanwhile the putative clinical relevance of these findings from bench work were discussed. Important aims are to gain more insight to mechanism of azole resistance and provide some efficient lead for prevention strategy.Entities:
Keywords: Aspergillus fumigatus; Azole resistance; Non-cyp51 mutation; Pathogenic fungi; cyp51 mutation
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Year: 2019 PMID： 32008963 DOI： 10.1016/j.mycmed.2019.100915
Source DB: PubMed Journal: J Mycol Med ISSN： 1156-5233 Impact factor: 2.391