Literature DB >> 3200826

The alpha and beta subunits of phosphorylase kinase are homologous: cDNA cloning and primary structure of the beta subunit.

M W Kilimann1, N F Zander, C C Kuhn, J W Crabb, H E Meyer, L M Heilmeyer.   

Abstract

We have cloned cDNA molecules encoding the beta subunit of phosphorylase kinase (ATP:phosphorylase-b phosphotransferase; EC 2.7.1.38) from rabbit fast-twitch skeletal muscle and have determined the complete primary structure of the polypeptide by a combination of peptide and DNA sequencing. In the mature beta subunit, the initial methionine is replaced by an acetyl group. The subunit is composed of 1092 amino acids and has a calculated molecular mass of 125,205 Da. Alignment of its sequence with the alpha subunit of phosphorylase kinase reveals extensive regions of homology, but each molecule also possesses unique sequences. Two of the three phosphorylation sites known for the beta subunit and all seven phosphorylation sites known for the alpha subunit are located in these unique domains.

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Year:  1988        PMID： 3200826      PMCID： PMC282756          DOI： 10.1073/pnas.85.24.9381

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  21 in total

1.  Isolation and properties of the active gamma subunit of phosphorylase kinase.

Authors:  S M Kee; D J Graves
Journal:  J Biol Chem       Date:  1986-04-05       Impact factor: 5.157

Review 2.  The role of protein phosphorylation in the hormonal control of enzyme activity.

Authors:  P Cohen
Journal:  Eur J Biochem       Date:  1985-09-16

3.  Multiple activities on phosphorylase kinase. 1. Characterization of three partial activities by their response to calcium ion, magnesium ion, pH, and ammonium chloride and effect of activation by phosphorylation and proteolysis.

Authors:  M W Kilimann; L M Heilmeyer
Journal:  Biochemistry       Date:  1982-04-13       Impact factor: 3.162

4.  High performance liquid chromatography purification and structural characterization of the subunits of rabbit muscle phosphorylase kinase.

Authors:  J W Crabb; L M Heilmeyer
Journal:  J Biol Chem       Date:  1984-05-25       Impact factor: 5.157

5.  Phosphorylase kinase from rabbit skeletal muscle: identification of the calmodulin-binding subunits.

Authors:  C Picton; C B Klee; P Cohen
Journal:  Eur J Biochem       Date:  1980-10

6.  Two-dimensional electron microscopic analysis of the chalice form of phosphorylase kinase.

Authors:  H J Schramm; H P Jennissen
Journal:  J Mol Biol       Date:  1985-02-20       Impact factor: 5.469

7.  A simple method for displaying the hydropathic character of a protein.

Authors:  J Kyte; R F Doolittle
Journal:  J Mol Biol       Date:  1982-05-05       Impact factor: 5.469

8.  Adenosine 5'-diphosphate as an allosteric effector of phosphorylase kinase from rabbit skeletal muscle.

Authors:  A Cheng; T J Fitzgerald; G M Carlson
Journal:  J Biol Chem       Date:  1985-02-25       Impact factor: 5.157

9.  Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein kinase.

Authors:  A Kishimoto; K Nishiyama; H Nakanishi; Y Uratsuji; H Nomura; Y Takeyama; Y Nishizuka
Journal:  J Biol Chem       Date:  1985-10-15       Impact factor: 5.157

10.  Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.

Authors:  M Kozak
Journal:  Cell       Date:  1986-01-31       Impact factor: 41.582
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  28 in total

1.  cDNA cloning of a liver isoform of the phosphorylase kinase alpha subunit and mapping of the gene to Xp22.2-p22.1, the region of human X-linked liver glycogenosis.

Authors:  J J Davidson; T Ozçelik; C Hamacher; P J Willems; U Francke; M W Kilimann
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-15       Impact factor: 11.205

Review 2.  Molecular genetics of phosphorylase kinase: cDNA cloning, chromosomal mapping and isoform structure.

Authors:  M W Kilimann
Journal:  J Inherit Metab Dis       Date:  1990       Impact factor: 4.982

Review 3.  Phosphorylase b kinase deficiency in man: a review.

Authors:  I E Van den Berg; R Berger
Journal:  J Inherit Metab Dis       Date:  1990       Impact factor: 4.982

4.  Autosomal recessive phosphorylase kinase deficiency in liver, caused by mutations in the gene encoding the beta subunit (PHKB).

Authors:  I E van den Berg; E A van Beurden; J B de Klerk; O P van Diggelen; H E Malingré; M M Boer; R Berger
Journal:  Am J Hum Genet       Date:  1997-09       Impact factor: 11.025

Review 5.  Genetic deficiencies of the glycogen phosphorylase system.

Authors:  J Hendrickx; P J Willems
Journal:  Hum Genet       Date:  1996-05       Impact factor: 4.132

6.  CrossSearch, a user-friendly search engine for detecting chemically cross-linked peptides in conjugated proteins.

Authors:  Owen W Nadeau; Gerald J Wyckoff; Justin E Paschall; Antonio Artigues; Jessica Sage; Maria T Villar; Gerald M Carlson
Journal:  Mol Cell Proteomics       Date:  2008-02-16       Impact factor: 5.911

7.  The association of phosphorylase kinase with membranes of rat liver smooth endoplasmic reticulum.

Authors:  G A Maridakis; T G Sotiroudis
Journal:  Mol Cell Biochem       Date:  1996-01-26       Impact factor: 3.396

8.  I/Lyn mouse phosphorylase kinase deficiency: mutation disrupts expression of the alpha/alpha'-subunit mRNAs.

Authors:  P K Bender; P A Lalley
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

9.  The quaternary structure of phosphorylase kinase as influenced by low concentrations of urea. Evidence suggesting a structural role for calmodulin.

Authors:  H K Paudel; G M Carlson
Journal:  Biochem J       Date:  1990-06-01       Impact factor: 3.857

10.  Expressed phosphorylase b kinase and its alphagammadelta subcomplex as regulatory models for the rabbit skeletal muscle holoenzyme.

Authors:  Igor G Boulatnikov; Jennifer L Peters; Owen W Nadeau; Jessica M Sage; Patrick J Daniels; Priyadarsini Kumar; Donal A Walsh; Gerald M Carlson
Journal:  Biochemistry       Date:  2009-10-27       Impact factor: 3.162
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