Angelo Di Vincenzo1, Marco Beghetto1, Roberto Vettor1, Claudio Tana2, Marco Rossato1, Dale S Bond3, Claudio Pagano4. 1. Department of Medicine, University of Padua, via Giustiniani 2, 35128, Padova, Italy. 2. Department of Medicine and Surgery, University of Parma, Parma, Italy. 3. The Miriam Hospital/Brown Alpert Medical School, Providence, RI, USA. 4. Department of Medicine, University of Padua, via Giustiniani 2, 35128, Padova, Italy. claudio.pagano@unipd.it.
Abstract
BACKGROUND: The aim of this study was to perform a meta-analysis on the effect of weight loss obtained by bariatric surgery or behavioral intervention on migraine frequency and indices of severity. MATERIALS AND METHODS: A search through Pubmed/Medline, ISI-web of knowledge, and Google Scholar retrieved 10 studies (n = 473). Selected outcomes were Headache Frequency, Pain Severity, Disability, and Attack Duration while BMI, BMI change, type of intervention (bariatric vs. behavioral), and type of population (adult vs. pediatric) were used for moderators and meta-regression analysis. RESULTS: Random effect meta-analysis shows that weight loss yields significant reductions in Headache Frequency (ES - 0.78, p < 0.0001), Pain Severity (ES - 1.04, p < 0.0001), Disability (ES -0.68, p < 0.0001), and Attack Duration (ES - 0.25, p = 0.017). Improvement in migraine was not correlated either to the degree of obesity at baseline or the degree of weight reduction. The effect on migraine was similar when weight reduction was obtained with bariatric surgery or behavioral intervention and was comparable in adult and pediatric populations. CONCLUSIONS: Weight loss improves characteristics of migraine headache in patients who have obesity independently of the type of intervention and the amount of weight loss. The mechanisms underlying the link between obesity, weight loss, and migraine headache may include chronic inflammation, obesity comorbidities, and overlapping behavioral and psychological risk factors.
BACKGROUND: The aim of this study was to perform a meta-analysis on the effect of weight loss obtained by bariatric surgery or behavioral intervention on migraine frequency and indices of severity. MATERIALS AND METHODS: A search through Pubmed/Medline, ISI-web of knowledge, and Google Scholar retrieved 10 studies (n = 473). Selected outcomes were Headache Frequency, Pain Severity, Disability, and Attack Duration while BMI, BMI change, type of intervention (bariatric vs. behavioral), and type of population (adult vs. pediatric) were used for moderators and meta-regression analysis. RESULTS: Random effect meta-analysis shows that weight loss yields significant reductions in Headache Frequency (ES - 0.78, p < 0.0001), Pain Severity (ES - 1.04, p < 0.0001), Disability (ES -0.68, p < 0.0001), and Attack Duration (ES - 0.25, p = 0.017). Improvement in migraine was not correlated either to the degree of obesity at baseline or the degree of weight reduction. The effect on migraine was similar when weight reduction was obtained with bariatric surgery or behavioral intervention and was comparable in adult and pediatric populations. CONCLUSIONS:Weight loss improves characteristics of migraine headache in patients who have obesity independently of the type of intervention and the amount of weight loss. The mechanisms underlying the link between obesity, weight loss, and migraine headache may include chronic inflammation, obesity comorbidities, and overlapping behavioral and psychological risk factors.
Entities:
Keywords:
Bariatric; Migraine; Obesity; Weight loss
Authors: Torsten Schröder; Gianna Kühn; Anna Kordowski; Soodeh Razeghi Jahromi; Astrid Gendolla; Stefan Evers; Charly Gaul; Diamant Thaçi; Inke Regina König; Christian Sina Journal: J Clin Med Date: 2022-02-20 Impact factor: 4.241
Authors: Mariarosaria Valente; Riccardo Garbo; Francesca Filippi; Alice Antonutti; Veronica Ceccarini; Yan Tereshko; Cherubino Di Lorenzo; Gian Luigi Gigli Journal: J Clin Med Date: 2022-08-23 Impact factor: 4.964
Authors: Eduardo Rivera-Mancilla; Linda Al-Hassany; Carlos M Villalón; Antoinette MaassenVanDenBrink Journal: Front Neurol Date: 2021-06-09 Impact factor: 4.003