BACKGROUND: Numerous cross-sectional studies report cognitive impairment in multiple sclerosis (MS), but longitudinal studies with sufficiently long-term follow-up are scarce. OBJECTIVE: We aimed to investigate the cognitive 10-year course of a cohort of MS patients. METHODS: 59 patients with clinically isolated syndrome (CIS) or relapsing-remitting (RR) MS were evaluated with Rao's Brief Repeatable Battery of Neuropsychological Tests at baseline and follow-up (at least 10 years later). They constituted 47.2% of 124 consecutive CIS and RRMS patients originally evaluated at baseline. Patients assessed at follow-up were well matched for baseline clinical characteristics with dropouts. RESULTS: The proportion of MS patients with overall cognitive impairment was increased by 10% within the 10-year period. When grouped on the basis of impairment in specific cognitive domains at baseline, patients originally impaired showed improvement at follow-up, while the opposite trend was observed for patients non-impaired at first assessment. A detailed case-by-case investigation revealed mixed evolution patterns, several patients fail in fewer domains at follow-up compared to baseline or failing at different domains at follow-up compared to baseline. CONCLUSIONS: This study suggests a more fluid picture for the evolution of cognitive function in a subgroup of MS patients and contradicts the concept of an inevitable, progressively evolving "dementia".
BACKGROUND: Numerous cross-sectional studies report cognitive impairment in multiple sclerosis (MS), but longitudinal studies with sufficiently long-term follow-up are scarce. OBJECTIVE: We aimed to investigate the cognitive 10-year course of a cohort of MSpatients. METHODS: 59 patients with clinically isolated syndrome (CIS) or relapsing-remitting (RR) MS were evaluated with Rao's Brief Repeatable Battery of Neuropsychological Tests at baseline and follow-up (at least 10 years later). They constituted 47.2% of 124 consecutive CIS and RRMS patients originally evaluated at baseline. Patients assessed at follow-up were well matched for baseline clinical characteristics with dropouts. RESULTS: The proportion of MSpatients with overall cognitive impairment was increased by 10% within the 10-year period. When grouped on the basis of impairment in specific cognitive domains at baseline, patients originally impaired showed improvement at follow-up, while the opposite trend was observed for patients non-impaired at first assessment. A detailed case-by-case investigation revealed mixed evolution patterns, several patients fail in fewer domains at follow-up compared to baseline or failing at different domains at follow-up compared to baseline. CONCLUSIONS: This study suggests a more fluid picture for the evolution of cognitive function in a subgroup of MSpatients and contradicts the concept of an inevitable, progressively evolving "dementia".
Authors: Lauren B Strober; Stephen M Rao; Jar-Chi Lee; Elizabeth Fischer; Richard Rudick Journal: Mult Scler Relat Disord Date: 2014-04-13 Impact factor: 4.339
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Authors: Steven R Schwid; Andrew D Goodman; Amy Weinstein; Michael P McDermott; Kenneth P Johnson Journal: J Neurol Sci Date: 2007-02-28 Impact factor: 3.181
Authors: Anat Achiron; Joab Chapman; David Magalashvili; Mark Dolev; Mor Lavie; Eran Bercovich; Michael Polliack; Glen M Doniger; Yael Stern; Olga Khilkevich; Shay Menascu; Gil Hararai; Micharel Gurevich; Yoram Barak Journal: PLoS One Date: 2013-08-01 Impact factor: 3.240
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