Wenjie He1, Xuhao Fang2, Xiaowei Wang3, Pan Gao3, Xing Gao2, Xi Zhou1, Renling Mao2, Jiani Hu4, Yanqing Hua2, Jun Xia5. 1. Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center; Shenzhen Second People's Hospital, 3002 SunGang Road West, Shenzhen, 518035, China. 2. Department of Neurosurgery, Huadong Hospital, Fudan University, 221 West Yan'an Road, Shanghai, China. 3. Department of Radiology, Huadong Hospital, Fudan University, 221 West Yan'an Road, Shanghai, China. 4. Department of Radiology, Wayne State University, Detroit, MI, 48201, USA. 5. Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center; Shenzhen Second People's Hospital, 3002 SunGang Road West, Shenzhen, 518035, China. xiajun@email.szu.edu.cn.
Abstract
PURPOSE: To recommend a new simple and explicit index termed the anteroposterior diameter of the lateral ventricle index (ALVI) for assessing brain ventricular size in neuroimaging and to compare Evans index (EI) between idiopathic normal pressure hydrocephalus (iNPH) patients and age-matched healthy elderly subjects. METHODS: Retrospective measurements of ventricular volume (VV), relative VV (RVV), the EI, and the ALVI were taken from thin-section CT scans for 23 pre-shunt-insertion iNPH patients and 62 age-matched healthy elderly volunteers. The area under the receiver operating characteristic (ROC) curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were calculated to assess the effectiveness of ALVI scores for predicting VV. RESULTS: The correlations between VV or RVV and ALVI scores (VV, r = 0.957; RVV, r = 0.983) were significantly stronger than the corresponding correlations with EI scores (VV, r = 0.843; RVV, r = 0.840). The AUC for ALVI scores was significantly greater than the AUC for EI scores. Furthermore, with the inclusion of the ALVI, the NRI value was 0.14 and the IDI value was 0.14; these improvements were also statistically significant. CONCLUSION: The ALVI is a more accurate and more explicitly defined marker of VV than the EI and assesses ventricular enlargement effectively. We suggest that ventricular enlargement of the healthy elderly be defined by ALVI > 0.50.
PURPOSE: To recommend a new simple and explicit index termed the anteroposterior diameter of the lateral ventricle index (ALVI) for assessing brain ventricular size in neuroimaging and to compare Evans index (EI) between idiopathic normal pressure hydrocephalus (iNPH) patients and age-matched healthy elderly subjects. METHODS: Retrospective measurements of ventricular volume (VV), relative VV (RVV), the EI, and the ALVI were taken from thin-section CT scans for 23 pre-shunt-insertion iNPH patients and 62 age-matched healthy elderly volunteers. The area under the receiver operating characteristic (ROC) curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were calculated to assess the effectiveness of ALVI scores for predicting VV. RESULTS: The correlations between VV or RVV and ALVI scores (VV, r = 0.957; RVV, r = 0.983) were significantly stronger than the corresponding correlations with EI scores (VV, r = 0.843; RVV, r = 0.840). The AUC for ALVI scores was significantly greater than the AUC for EI scores. Furthermore, with the inclusion of the ALVI, the NRI value was 0.14 and the IDI value was 0.14; these improvements were also statistically significant. CONCLUSION: The ALVI is a more accurate and more explicitly defined marker of VV than the EI and assesses ventricular enlargement effectively. We suggest that ventricular enlargement of the healthy elderly be defined by ALVI > 0.50.
Entities:
Keywords:
Anteroposterior diameter of the lateral ventricle index; Evans’ index; Idiopathic normal-pressure hydrocephalus; Lateral ventricular volume
Authors: Minrui Lv; Xiaolin Yang; Xi Zhou; Jiakuan Chen; Haihua Wei; Duanming Du; Hai Lin; Jun Xia Journal: Front Neurol Date: 2022-09-07 Impact factor: 4.086