Sibel Bakirci1,2, Dilek Solmaz1,2, Wilson Stephenson1,2, Lihi Eder1,2, Johannes Roth1,2, Sibel Zehra Aydin3,4. 1. From the Faculty of Medicine, Division of Rheumatology, and the Division of Internal Medicine, University of Ottawa, Ottawa; Women's College Research Institute, Women's College Hospital; Department of Medicine, University of Toronto, Toronto; Division of Pediatric Dermatology and Rheumatology, Children's Hospital of Eastern Ontario; The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. 2. S. Bakirci, MD, Faculty of Medicine, Division of Rheumatology, University of Ottawa; D. Solmaz, MD, Faculty of Medicine, Division of Rheumatology, University of Ottawa; W. Stephenson, MD, Faculty of Medicine, Division of Internal Medicine, University of Ottawa; L. Eder, MD, PhD, Women's College Research Institute, Women's College Hospital and the Department of Medicine, University of Toronto; J. Roth, MD, University of Ottawa, Chief, Division of Pediatric Dermatology and Rheumatology, Children's Hospital of Eastern Ontario; S.Z. Aydin, MD, Faculty of Medicine, Division of Rheumatology, University of Ottawa, and the Ottawa Hospital Research Institute. 3. From the Faculty of Medicine, Division of Rheumatology, and the Division of Internal Medicine, University of Ottawa, Ottawa; Women's College Research Institute, Women's College Hospital; Department of Medicine, University of Toronto, Toronto; Division of Pediatric Dermatology and Rheumatology, Children's Hospital of Eastern Ontario; The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. saydin@toh.ca. 4. S. Bakirci, MD, Faculty of Medicine, Division of Rheumatology, University of Ottawa; D. Solmaz, MD, Faculty of Medicine, Division of Rheumatology, University of Ottawa; W. Stephenson, MD, Faculty of Medicine, Division of Internal Medicine, University of Ottawa; L. Eder, MD, PhD, Women's College Research Institute, Women's College Hospital and the Department of Medicine, University of Toronto; J. Roth, MD, University of Ottawa, Chief, Division of Pediatric Dermatology and Rheumatology, Children's Hospital of Eastern Ontario; S.Z. Aydin, MD, Faculty of Medicine, Division of Rheumatology, University of Ottawa, and the Ottawa Hospital Research Institute. saydin@toh.ca.
Abstract
OBJECTIVE: We aimed to investigate the prevalence of ultrasonographic (US) lesions in healthy entheses and contributing factors. METHODS: US scans were performed on 960 entheses of 80 healthy subjects. Factors contributing to entheseal changes were investigated with regression analysis. RESULTS: Thickening (20.4% of the entheses) and enthesophytes (23.1%) were the most common inflammatory and structural damage lesions, respectively. Age (p < 0.001), male sex (p = 0.003), body mass index (BMI; p = 0.001), and high physical activity (p = 0.007) were independent predictors of enthesitis scores on US. CONCLUSION: The effects of age, sex, BMI, and physical activity on the entheses need to be considered when differentiating disease from health.
OBJECTIVE: We aimed to investigate the prevalence of ultrasonographic (US) lesions in healthy entheses and contributing factors. METHODS: US scans were performed on 960 entheses of 80 healthy subjects. Factors contributing to entheseal changes were investigated with regression analysis. RESULTS: Thickening (20.4% of the entheses) and enthesophytes (23.1%) were the most common inflammatory and structural damage lesions, respectively. Age (p < 0.001), male sex (p = 0.003), body mass index (BMI; p = 0.001), and high physical activity (p = 0.007) were independent predictors of enthesitis scores on US. CONCLUSION: The effects of age, sex, BMI, and physical activity on the entheses need to be considered when differentiating disease from health.
Authors: David Simon; Arnd Kleyer; Sara Bayat; Johannes Knitza; Larissa Valor-Mendez; Marina Schweiger; Georg Schett; Koray Tascilar; Axel J Hueber Journal: Arthritis Res Ther Date: 2021-06-21 Impact factor: 5.156