Zayd Tippu1, Lewis Au2, Samra Turajlic3. 1. Renal and Skin Units, The Royal Marsden Hospital NHS Foundation Trust, London, UK. 2. Renal and Skin Units, The Royal Marsden Hospital NHS Foundation Trust, London, UK; The Francis Crick Institute, London, UK. 3. Renal and Skin Units, The Royal Marsden Hospital NHS Foundation Trust, London, UK; The Francis Crick Institute, London, UK. Electronic address: s.turajlic@crick.ac.uk.
Abstract
A diverse range of clinical phenotypes are observed in clear-cell renal cell carcinoma (ccRCC) with resultant therapeutic implications. Molecular characterisation underpinning the diversity observed has been qualified, where the near ubiquitous loss of the short arm of chromosome 3 precedes distinct evolutionary trajectories involving different sequences and combinations of genetic events. Primary tumours are characterised by varying degrees of intratumoural heterogeneity and chromosomal complexity associated with distinct metastatic phenotypes. An evolutionary understanding reconciles the diverse clinical phenotypes observed in metastatic ccRCC and has the potential to impact patient management. PATIENT SUMMARY: Re-tracing the evolutionary paths taken by clear-cell kidney cancer through analyses at the gene level gives an insight into genetic changes that are correlated to metastatic potential. This may provide a framework to guide therapeutic interventions, especially in identifying candidates for surgical intervention. Crown
A diverse range of clinical phenotypes are observed in clear-cell renal cell carcinoma (ccRCC) with resultant therapeutic implications. Molecular characterisation underpinning the diversity observed has been qualified, where the near ubiquitous loss of the short arm of chromosome 3 precedes distinct evolutionary trajectories involving different sequences and combinations of genetic events. Primary tumours are characterised by varying degrees of intratumoural heterogeneity and chromosomal complexity associated with distinct metastatic phenotypes. An evolutionary understanding reconciles the diverse clinical phenotypes observed in metastatic ccRCC and has the potential to impact patient management. PATIENT SUMMARY: Re-tracing the evolutionary paths taken by clear-cell kidney cancer through analyses at the gene level gives an insight into genetic changes that are correlated to metastatic potential. This may provide a framework to guide therapeutic interventions, especially in identifying candidates for surgical intervention. Crown
Authors: Robert J Motzer; Jean-François Martini; Keith A Ching; Alain Ravaud; Xinmeng J Mu; Michael Staehler; Daniel J George; Olga Valota; Xun Lin; Hardev S Pandha Journal: Nat Commun Date: 2022-10-10 Impact factor: 17.694