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Literature DB >> 32006298

Calix[4]API-s: fully functionalized calix[4]arene-based facial active pharmaceutical ingredients.

Abstract

This mini-review covers 25 fully functionalized facial calix[4]arene-based symmetrical and conical cyclic tetramers with significant (comparable to established therapeutic agents) anticancer and anti-infective activities. The main role of the calixarene scaffold in these calix[4]arene-based active pharmaceutical ingredients (calix[4]API-s) is to replicate embedded phenolic units in the cyclic tetramers. So, probably owing to the multivalency, facial, conical structures of calix[4]API-s and synergistic effect of their four replicated units, they can be considered as effective bioactive agents.

Entities: Chemical

Keywords: Active pharmaceutical ingredient; Anti-infective; Anticancer; Calix[4]arene; Cyclic tetramer

Year: 2020 PMID： 32006298 DOI： 10.1007/s11030-020-10042-0

Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 2.943

25 in total

1. Design of nonpeptidic topomimetics of antiangiogenic proteins with antitumor activities.

Authors: Ruud P M Dings; Xuemei Chen; Debby M E I Hellebrekers; Loes I van Eijk; Ying Zhang; Thomas R Hoye; Arjan W Griffioen; Kevin H Mayo
Journal: J Natl Cancer Inst Date: 2006-07-05 Impact factor: 13.506

2. Synthesis, X-ray crystal structure and anti-tumor activity of calix[n]arene polyhydroxyamine derivatives.

Authors: Lin An; Li-Li Han; You-Guang Zheng; Xian-Na Peng; Yun-Sheng Xue; Xiao-Ke Gu; Jing Sun; Chao-Guo Yan
Journal: Eur J Med Chem Date: 2016-07-15 Impact factor: 6.514

Review 3. Calixdrugs: calixarene-based clusters of established therapeutic drug agents.

Authors: Fazel Nasuhi Pur
Journal: Mol Divers Date: 2016-03-26 Impact factor: 2.943

4. OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis.

Authors: Lucile Astorgues-Xerri; Maria E Riveiro; Annemilaï Tijeras-Raballand; Maria Serova; Gabriel A Rabinovich; Ivan Bieche; Michel Vidaud; Armand de Gramont; Mathieu Martinet; Esteban Cvitkovic; Sandrine Faivre; Eric Raymond
Journal: Eur J Cancer Date: 2014-07-16 Impact factor: 9.162

5. Enhancement of T-cell-mediated antitumor response: angiostatic adjuvant to immunotherapy against cancer.

Authors: Ruud P M Dings; Kieng B Vang; Karolien Castermans; Flavia Popescu; Yan Zhang; Mirjam G A Oude Egbrink; Matthew F Mescher; Michael A Farrar; Arjan W Griffioen; Kevin H Mayo
Journal: Clin Cancer Res Date: 2011-01-20 Impact factor: 12.531

6. Multivalent presentation of a hydrolytically stable GM(3) lactone mimetic as modulator of melanoma cells motility and adhesion.

Authors: Barbara Richichi; Giuseppina Comito; Linda Cerofolini; Gabriele Gabrielli; Alberto Marra; Lisa Moni; Alice Pace; Lucia Pasquato; Paola Chiarugi; Alessandro Dondoni; Lucio Toma; Cristina Nativi
Journal: Bioorg Med Chem Date: 2013-03-24 Impact factor: 3.641

2. Synthesis of novel calix[4]arene p-benzazole derivatives and investigation of their DNA binding and cleavage activities with molecular docking and experimental studies.

Authors: Seyda Cigdem Ozkan; Fatma Aksakal; Aydan Yilmaz
Journal: RSC Adv Date: 2020-10-21 Impact factor: 4.036

2 in total

Calix[4]API-s: fully functionalized calix[4]arene-based facial active pharmaceutical ingredients.

1. Design of nonpeptidic topomimetics of antiangiogenic proteins with antitumor activities.

2. Synthesis, X-ray crystal structure and anti-tumor activity of calix[n]arene polyhydroxyamine derivatives.

Review 3. Calixdrugs: calixarene-based clusters of established therapeutic drug agents.

4. OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis.

5. Enhancement of T-cell-mediated antitumor response: angiostatic adjuvant to immunotherapy against cancer.

6. Multivalent presentation of a hydrolytically stable GM(3) lactone mimetic as modulator of melanoma cells motility and adhesion.

Review 7. From chemoprevention to chemotherapy: common targets and common goals.

8. Polycationic calixarene PTX013, a potent cytotoxic agent against tumors and drug resistant cancer.

9. Antitumor agent calixarene 0118 targets human galectin-1 as an allosteric inhibitor of carbohydrate binding.

10. Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008.

1. Membrane-Active Antibacterial Agents Based on Calix[4]arene Derivatives: Synthesis and Biological Evaluation.

2. Synthesis of novel calix[4]arene p-benzazole derivatives and investigation of their DNA binding and cleavage activities with molecular docking and experimental studies.