Fredrik Jansson1,2, Folke Folkvaljon3, Pär Stattin3, Ola Bratt4, Olof Akre1,5. 1. Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweeden. 2. Department of Surgery and Urology, Danderyd Hospital, Stockholm, Sweeden. 3. Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweeden. 4. Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. 5. Department of Urology, Karolinska University Hospital, Stockholm, Sweeden.
Abstract
PURPOSE: We investigated whether men with biopsy verified, low grade cancer and a family history of lethal or advanced prostate cancer are at particularly high risk for harboring undetected high grade disease. MATERIALS AND METHODS: Upgrading and up staging of prostate cancer are common after prostatectomy. In a nationwide population based cohort we identified 6,854 men with low risk prostate cancer who underwent radical prostatectomy. Among these men 1,739 (25%) had a history of prostate cancer in a first-degree relative and 289 (4%) had a first-degree relative with lethal or advanced prostate cancer. RESULTS: Compared to men with no familial occurrence of prostate cancer, the odds ratio for the risk of up staging among men with a familial occurrence of high risk or lethal prostate cancer was 1.06 (95% CI 0.76-1.47). The corresponding odds ratio for upgrading was 1.17 (0.91-1.50). CONCLUSIONS: We found no association between family history of prostate cancer and up staging or upgrading after radical prostatectomy.
PURPOSE: We investigated whether men with biopsy verified, low grade cancer and a family history of lethal or advanced prostate cancer are at particularly high risk for harboring undetected high grade disease. MATERIALS AND METHODS: Upgrading and up staging of prostate cancer are common after prostatectomy. In a nationwide population based cohort we identified 6,854 men with low risk prostate cancer who underwent radical prostatectomy. Among these men 1,739 (25%) had a history of prostate cancer in a first-degree relative and 289 (4%) had a first-degree relative with lethal or advanced prostate cancer. RESULTS: Compared to men with no familial occurrence of prostate cancer, the odds ratio for the risk of up staging among men with a familial occurrence of high risk or lethal prostate cancer was 1.06 (95% CI 0.76-1.47). The corresponding odds ratio for upgrading was 1.17 (0.91-1.50). CONCLUSIONS: We found no association between family history of prostate cancer and up staging or upgrading after radical prostatectomy.
Authors: Ghalib A Jibara; Marlon Perera; Emily A Vertosick; Daniel D Sjoberg; Andrew Vickers; Peter T Scardino; James A Eastham; Vincent P Laudone; Karim Touijer; Xin Lin; Maria I Carlo; Behfar Ehdaie Journal: J Urol Date: 2022-04-04 Impact factor: 7.600
Authors: Kathleen Herkommer; Nikola Maier; Donna P Ankerst; Stefan Schiele; Jürgen E Gschwend; Valentin H Meissner Journal: World J Urol Date: 2020-10-13 Impact factor: 4.226