Long noncoding RNA RHPN1-AS1, induced by KDM5B, is involved in breast cancer via sponging miR-6884-5p.

Breast cancer (BC) has been featured with high incidence and mortality rate in women on the globe. The critical roles of long noncoding RNAs (lncRNAs) in cancer initiation and progression have been deciphered in the past few years. RHPN1 antisense RNA 1 (RHPN1-AS1) has been reported as correlated with uveal melanoma and non-small cell lung cancer, whereas the function of RHPN1-AS1 in BC is still masked. KDM5B has been unveiled as a potential oncogene in BC while the mechanism that KDM5B regulates BC progression via modulating lncRNAs is veiled to a large extent. Herein we discovered overexpression of KDM5B in dendritic cells tissues and cells. Knockdown of KDM5B impeded the viability and migration of BC cells. Moreover, we observed repressed RHPN1-AS1 in the presence of depleted KDM5B and KDM5B exerted its oncogenic role in BC through RHPN1-AS1. RHPN1-AS1 was elevated in BC tissues and cells. Higher RHPN1-AS1 expression was associated with poorer prognosis of patients with BC. Silence of RHPN1-AS1 repressed BC cell growth and migration. Mechanically, we found RHPN1-AS1 acted as a molecular sponge of miR-6884-5p and thus deregulate Annexin A11 (ANXA11), a target gene of miR-6884-5p. Rescue assay further validated that RHPN1-AS1 contributed to BC progression by regulating the miR-6884-5p/ANXA11 axis. Taken together, this study revealed that RHPN1-AS1 was induced by KDM5B and promoted BC via the RHPN1-AS1/miR-6884-5p/ANXA11 pathway. These results and findings could shed novel light on BC tumorigenesis.