Andreas Ronit1,2, Thomas Benfield2, Jens Lundgren3, Jørgen Vestbo4, Shoaib Afzal5,6,7, Børge G Nordestgaard5,6,7, Jørgen Tobias Kühl8,9, Klaus F Kofoed8,9, Susanne Dam Nielsen1, Thomas Kristensen9. 1. Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. 2. Department of Infectious Diseases 144, Amager Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark. 3. Copenhagen HIV Program, Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. 4. Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, United Kingdom. 5. Copenhagen General Population Study, Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark. 6. Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark. 7. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. 8. Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. 9. Department of Radiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Abstract
BACKGROUND: Chest computed tomography (CT) findings in well-treated people with HIV infection (PWH) remain poorly characterized. METHODS: Cross-sectional analysis examining interstitial chest CT findings in PWH (n = 754) and uninfected controls (n = 470). RESULTS: HIV infection was independently associated with 1.82 (95% CI, 1.18-2.88) and 5.15 (95% CI, 1.72-22.2) higher adjusted odds of any interstitial lung abnormality and findings suspicious for interstitial lung disease, respectively. CONCLUSIONS: HIV infection was independently associated with interstitial lung abnormalities and findings suspicious for interstitial lung disease. Whether these abnormalities develop into more recognizable disease states over time is unknown but warrants further investigation.
BACKGROUND: Chest computed tomography (CT) findings in well-treated people with HIV infection (PWH) remain poorly characterized. METHODS: Cross-sectional analysis examining interstitial chest CT findings in PWH (n = 754) and uninfected controls (n = 470). RESULTS:HIV infection was independently associated with 1.82 (95% CI, 1.18-2.88) and 5.15 (95% CI, 1.72-22.2) higher adjusted odds of any interstitial lung abnormality and findings suspicious for interstitial lung disease, respectively. CONCLUSIONS:HIV infection was independently associated with interstitial lung abnormalities and findings suspicious for interstitial lung disease. Whether these abnormalities develop into more recognizable disease states over time is unknown but warrants further investigation.
Authors: Sarath Raju; Jacquie Astemborski; Michael Bradley Drummond; Hema C Ramamurthi; Jing Sun; Robert H Brown; Gregory D Kirk; Meredith C McCormack Journal: J Acquir Immune Defic Syndr Date: 2022-01-01 Impact factor: 3.771