BACKGROUND: There are limited reports of uveal "melanocytic" lesions in patients with oculocutaneous albinism, with no reports from Asia. OBJECTIVES: In this study, we report 3 eyes with uveal "melanocytic" lesions in Asian patients with oculocutaneous albinism. METHODS: Retrospective small case series. Three eyes of 2 Asian patients with oculocutaneous albinism were included. Case 1 was a 54-year-old female who presented with juxtapapillary choroidal melanoma and underwent enucleation. Case 2 was a 39-year-old male with pigmented choroidal nevus in the right eye and suspicious nevus/choroidal variegation in the left eye. RESULTS: For case 1, metastatic workup including ultrasound of the abdomen, liver function test, and chest X-ray was unremarkable. Magnetic resonance imaging of the cranium ruled out extraocular extension. The left eye was enucleated due to the large tumor size and poor visual potential, and histopathological examination confirmed the diagnosis of choroidal melanoma with mixed cell type. At the last follow-up 6 months after enucleation, there was no evidence of metastasis. Case 2 was observed. CONCLUSION: Pigmented choroidal nevus and melanoma are rarely observed in patients with oculocutaneous albinism.
BACKGROUND: There are limited reports of uveal "melanocytic" lesions in patients with oculocutaneous albinism, with no reports from Asia. OBJECTIVES: In this study, we report 3 eyes with uveal "melanocytic" lesions in Asian patients with oculocutaneous albinism. METHODS: Retrospective small case series. Three eyes of 2 Asian patients with oculocutaneous albinism were included. Case 1 was a 54-year-old female who presented with juxtapapillary choroidal melanoma and underwent enucleation. Case 2 was a 39-year-old male with pigmented choroidal nevus in the right eye and suspicious nevus/choroidal variegation in the left eye. RESULTS: For case 1, metastatic workup including ultrasound of the abdomen, liver function test, and chest X-ray was unremarkable. Magnetic resonance imaging of the cranium ruled out extraocular extension. The left eye was enucleated due to the large tumor size and poor visual potential, and histopathological examination confirmed the diagnosis of choroidal melanoma with mixed cell type. At the last follow-up 6 months after enucleation, there was no evidence of metastasis. Case 2 was observed. CONCLUSION: Pigmented choroidal nevus and melanoma are rarely observed in patients with oculocutaneous albinism.
Authors: Pukhraj Rishi; Carol L Shields; Mohammed Ali Khan; Kaitlin Patrick; Jerry A Shields Journal: Ophthalmology Date: 2013-09 Impact factor: 12.079
Authors: Renato Marchiori Bakos; Giuseppe Argenziano; Iris Zalaudek; Nathalia C M S Masiero; Gabriela Zoratto; André Cartell; Lucio Bakos Journal: J Am Acad Dermatol Date: 2009-03 Impact factor: 11.527