AIM: To compare the incidence of surgical site infection with different antibiotic regimes in elective total knee arthroplasty. We hypothesise that a single high dose of Teicoplanin and Gentamicin is as effective as other regimes. METHODS: A retrospective study of prospectively collected data on a total of 4500 elective knee replacements over a 9-year period was conducted in a district general hospital. Data were collected on antibiotic regime, patient characteristics, infection (treatment, infective agents, sensitivities) and complications. RESULTS: Five different antibiotic regimes that have been used in elective knee arthroplasty were identified in our institution. 40 patients in total were identified who had a deep infection. Rates of deep surgical site infection were not significantly different between the five groups (p = 0.83). CONCLUSION: A single pre-operative dose of Teicoplanin and Gentamicin has similar efficacy of prophylaxis to other regimes for patients undergoing primary elective total knee replacements. We recommend the choice of prophylaxis regimen is made locally based on pathogen virulence, drug resistance and cost.
AIM: To compare the incidence of surgical site infection with different antibiotic regimes in elective total knee arthroplasty. We hypothesise that a single high dose of Teicoplanin and Gentamicin is as effective as other regimes. METHODS: A retrospective study of prospectively collected data on a total of 4500 elective knee replacements over a 9-year period was conducted in a district general hospital. Data were collected on antibiotic regime, patient characteristics, infection (treatment, infective agents, sensitivities) and complications. RESULTS: Five different antibiotic regimes that have been used in elective knee arthroplasty were identified in our institution. 40 patients in total were identified who had a deep infection. Rates of deep surgical site infection were not significantly different between the five groups (p = 0.83). CONCLUSION: A single pre-operative dose of Teicoplanin and Gentamicin has similar efficacy of prophylaxis to other regimes for patients undergoing primary elective total knee replacements. We recommend the choice of prophylaxis regimen is made locally based on pathogen virulence, drug resistance and cost.
Authors: Kayode O Oduwole; Diarmuid C Molony; Ray J Walls; Simi P Bashir; Kevin J Mulhall Journal: Knee Surg Sports Traumatol Arthrosc Date: 2010-02-11 Impact factor: 4.342
Authors: Hilal Maradit Kremers; Sue L Visscher; James P Moriarty; Megan S Reinalda; Walter K Kremers; James M Naessens; David G Lewallen Journal: Clin Orthop Relat Res Date: 2013-01 Impact factor: 4.176
Authors: Marjo E E van Kasteren; Judith Manniën; Alewijn Ott; Bart-Jan Kullberg; Annette S de Boer; Inge C Gyssens Journal: Clin Infect Dis Date: 2007-02-14 Impact factor: 9.079