| Literature DB >> 32001098 |
Marek Marzec1, Agnieszka Brąszewska-Zalewska2, Goetz Hensel3.
Abstract
Precise and efficient use of genome editing tools are hampered by the introduction of DNA double-strand breaks, donor DNA templates, or homology-directed repair. A recent study expands the genome editing toolbox with the introduction of prime editing, which overcomes previous challenges and introduces insertions, deletions, and all putative 12 types of base-to-base conversions in human cells.Entities:
Keywords: CRISPR-Cas9; genome editing; prime editing; targeted mutagenesis
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Year: 2020 PMID： 32001098 DOI： 10.1016/j.tcb.2020.01.004
Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808