Alexandru Mester1, Alexandra Iulia Irimie2, Alina Tanase3, Sebastian Tranca4, Radu Septimiu Campian1, Ciprian Tomuleasa5, Delia Dima5, Andra Piciu6, Ondine Lucaciu1. 1. Department of Oral Health, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania. 2. Department of Propedeutics, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania. 3. Department of Stem Cell Transplantation, Fundeni Clinical Institute, Bucharest, Romania. 4. Department of Intensive Care Unit, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania. 5. Department of Hematology, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania. 6. Department of Medical Oncology, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania. Electronic address: piciuandra@gmail.com.
Abstract
PURPOSE: The aim of this systematic review was to determine a potential association between periodontal disease and graft versus host disease (GVHD). DESIGN: PubMed, Scopus and Web of Science databases were searched to identify all relevant articles. The eligibility criteria were prospective, retrospective, cross-sectional, cohort, case-control studies and interventional studies that assessed periodontal parameters in GVHD adults' patients. RESULTS: Seven studies, published between 2000 and 2018, were eligible. The aggravation of periodontal tissues is due to inadequate oral hygiene, dental plaque, decays, gum recession, retained roots, tooth loss, periodontally infected teeth. Several studies have indicated that periodontitis treatment performed before transplantation showed the reduction of gingival inflammation and maintenance of periodontal health. CONCLUSIONS: Periodontitis might be a risk factor for GVHD. However, due to the limited number of studies included in the review and their heterogeneity, more data are needed to sustain the correlation between periodontitis and GVHD.
PURPOSE: The aim of this systematic review was to determine a potential association between periodontal disease and graft versus host disease (GVHD). DESIGN: PubMed, Scopus and Web of Science databases were searched to identify all relevant articles. The eligibility criteria were prospective, retrospective, cross-sectional, cohort, case-control studies and interventional studies that assessed periodontal parameters in GVHD adults' patients. RESULTS: Seven studies, published between 2000 and 2018, were eligible. The aggravation of periodontal tissues is due to inadequate oral hygiene, dental plaque, decays, gum recession, retained roots, tooth loss, periodontally infected teeth. Several studies have indicated that periodontitis treatment performed before transplantation showed the reduction of gingival inflammation and maintenance of periodontal health. CONCLUSIONS:Periodontitis might be a risk factor for GVHD. However, due to the limited number of studies included in the review and their heterogeneity, more data are needed to sustain the correlation between periodontitis and GVHD.
Authors: Kirsten M Williams; Yoshihiro Inamoto; Annie Im; Betty Hamilton; John Koreth; Mukta Arora; Iskra Pusic; Jacqueline W Mays; Paul A Carpenter; Leo Luznik; Pavan Reddy; Jerome Ritz; Hildegard Greinix; Sophie Paczesny; Bruce R Blazar; Joseph Pidala; Corey Cutler; Daniel Wolff; Kirk R Schultz; Steven Z Pavletic; Stephanie J Lee; Paul J Martin; Gerard Socie; Stefanie Sarantopoulos Journal: Transplant Cell Ther Date: 2021-03-02