| Literature DB >> 3199805 |
R McCague1, M Jarman, O T Leung, A B Foster, G Leclercq, S Stoessel.
Abstract
Three types of non-isomerisable antiestrogens analogous to tamoxifen and 4-hydroxytamoxifen are described. Advantages of non-isomerisability are simplified synthesis, simplified metabolism profile, and that structure-activity relationships become more meaningful. The compounds described differ from tamoxifen by having an extra ring methyl group, a fused seven-membered ring system, or the central ethylene linkage saturated. These compounds retained both binding affinity to estrogen receptors and growth inhibition of MCF-7 human breast cancer cells in vitro.Entities:
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Year: 1988 PMID： 3199805 DOI： 10.1016/0022-4731(88)90005-2
Source DB: PubMed Journal: J Steroid Biochem ISSN： 0022-4731 Impact factor: 4.292