Literature DB >> 31997036

Origins of the Crisis in Insulin Affordability and Practical Advice for Clinicians on Using Human Insulin.

Jing Luo1, Walid F Gellad2,3.   

Abstract

PURPOSE OF REVIEW: High insulin prices and cost-related insulin underuse are increasingly common and vexing problems for healthcare providers. This review highlights several factors that contribute to high prices and limited generic competition in the US insulin market. RECENT
FINDINGS: An opaque and complex pricing and reimbursement system for insulin, allegations of collusive practices by insulin manufacturers, and a lack of generic competition drive and sustain high insulin prices. When combined with increasing insurance deductibles and cost sharing, these factors contribute to cost-related insulin underuse and are associated with adverse clinical outcomes. Healthcare providers facing patients with type 2 diabetes who struggle to afford insulin should consider initiating or switching from analogue to human insulin as one way to help address the challenges of access and affordability. However, it is also important to support initiatives to advocate for affordable pricing for insulin for patients who can benefit from the flexibility offered by many of the newer insulin preparations.

Entities:  

Keywords:  Human insulin; Insulin prices; Insulin switching

Mesh:

Substances:

Year:  2020        PMID: 31997036      PMCID: PMC9036473          DOI: 10.1007/s11892-020-1286-3

Source DB:  PubMed          Journal:  Curr Diab Rep        ISSN: 1534-4827            Impact factor:   5.430


  35 in total

1.  Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes. HOE 901/3002 Study Group.

Authors:  H Yki-Järvinen; A Dressler; M Ziemen
Journal:  Diabetes Care       Date:  2000-08       Impact factor: 19.112

2.  Why is there no generic insulin? Historical origins of a modern problem.

Authors:  Jeremy A Greene; Kevin R Riggs
Journal:  N Engl J Med       Date:  2015-03-19       Impact factor: 91.245

3.  The Price of Crossing the Border for Medications.

Authors:  Michael Fralick; Jerry Avorn; Aaron S Kesselheim
Journal:  N Engl J Med       Date:  2017-07-27       Impact factor: 91.245

4.  State Initiatives to Control Medication Costs--Can Transparency Legislation Help?

Authors:  Ameet Sarpatwari; Jerry Avorn; Aaron S Kesselheim
Journal:  N Engl J Med       Date:  2016-06-16       Impact factor: 91.245

5.  Inaccurate Reporting of Insulin Reimbursement.

Authors:  Jenny Bryant
Journal:  JAMA Intern Med       Date:  2016-03       Impact factor: 21.873

6.  The Cost of Diabetes Care-An Elephant in the Room.

Authors:  Matthew C Riddle; William H Herman
Journal:  Diabetes Care       Date:  2018-05       Impact factor: 19.112

Review 7.  9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes-2019.

Authors: 
Journal:  Diabetes Care       Date:  2019-01       Impact factor: 19.112

8.  Trends in Medicaid Prices, Market Share, and Spending on Long-Acting Insulins, 2006-2018.

Authors:  Inmaculada Hernandez; Chester B Good; William H Shrank; Walid F Gellad
Journal:  JAMA       Date:  2019-04-23       Impact factor: 56.272

Review 9.  Long-acting insulin analogues versus NPH insulin (human isophane insulin) for type 2 diabetes mellitus.

Authors:  K Horvath; K Jeitler; A Berghold; S H Ebrahim; T W Gratzer; J Plank; T Kaiser; T R Pieber; A Siebenhofer
Journal:  Cochrane Database Syst Rev       Date:  2007-04-18

10.  The Affordable Care Act Insurance Reforms: Where Are We Now, and What's Next?

Authors:  M Claire Borelli; Miryam Bujanda; Krista Maier
Journal:  Clin Diabetes       Date:  2016-01
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  2 in total

1.  National Trends in Out-of-Pocket Costs Among U.S. Adults With Diabetes Aged 18-64 Years: 2001-2017.

Authors:  Yu Wang; Joohyun Park; Rui Li; Elizabeth Luman; Ping Zhang
Journal:  Diabetes Care       Date:  2021-08-24       Impact factor: 17.152

2.  Trends in Insulin Types and Devices Used by Adults With Type 2 Diabetes in the United States, 2016 to 2020.

Authors:  Sudipa Sarkar; James Heyward; G Caleb Alexander; Rita R Kalyani
Journal:  JAMA Netw Open       Date:  2021-10-01
  2 in total

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