Agnieszka Słowik1, Paweł Jagielski2, Paweł Potocki1, Joanna Streb1, Sebastian Ochenduszko3, Piotr Wysocki1, Grzegorz Gajos4, Ewa Konduracka5. 1. Department of Oncology, Jagiellonian University Medical College, Kraków, Poland 2. Human Nutrition Department,Faculty of Health Science, Jagiellonian University Medical College, Kraków, Poland 3. Department of Medical Oncology, Dr. Peset University Hospital, Valencia, Spain 4. Department of Coronary Disease and Heart Failure, Jagiellonian University Medical College, Kraków, Poland; Institute of Cardiology, John Paul II Hospital, Kraków, Poland 5. Department of Coronary Disease and Heart Failure, Jagiellonian University Medical College, Kraków, Poland; Institute of Cardiology, John Paul II Hospital, Kraków, Poland. ekonduracka@interia.eu
Abstract
BACKGROUND:Anthracycline‑induced cardiotoxicity (AIC) remains the main long‑term irreversible side effect in malignancy survivors. Cardiotoxicity prevention is one of the most reasonable approaches. AIMS: In this prospective randomized open‑label study, we aimed to verify whether ramipril protects from early‑onset AIC in women with breast cancer (BC). METHODS: We analyzed data from 96 women (median age, 47 years) with BC after breast surgery, without significant cardiovascular diseases, who were eligible for adjuvant anthracyclines. They were randomized to a ramipril or control arm. Cardiotoxicity was estimated with repeat echocardiography and themeasurement of troponin I and N‑terminal fragment of the prohormone brain natriuretic peptide (NT‑proBNP) levels over 1‑year follow‑up. Anthracycline‑induced cardiotoxicity was defined as a decrease in left ventricular ejection fraction (LVEF), elevated biomarker levels, and/or occurrence of heart failure (HF) or cardiac death. RESULTS: A decrease in LVEF above 10‑percent points occurred in 6.3% of ramipril patients and 18.5% ofcontrols (P = 0.15). No cases of HF, cardiac death, or LVEF decline below 50% were reported. The percentage of patients with elevated NT‑proBNP levels increased with time in controls (P = 0.003) and remained unchanged in the ramipril arm. At the end of follow‑up, an increase in NT‑proBNP levels was more common and decline was less common in the control than ramipril arm (P = 0.01). No significant differences in troponin levels were found between the study arms. Ramipril was well tolerated in normotensive women. CONCLUSIONS: In relatively young women with BC without serious comorbidities, who received anthracyclines, 1‑year treatment with ramipril exerts potentially protective effects on cardiotoxicity assessed with NT‑proBNP levels.
RCT Entities:
BACKGROUND:Anthracycline‑induced cardiotoxicity (AIC) remains the main long‑term irreversible side effect in malignancy survivors. Cardiotoxicity prevention is one of the most reasonable approaches. AIMS: In this prospective randomized open‑label study, we aimed to verify whether ramipril protects from early‑onset AIC in women with breast cancer (BC). METHODS: We analyzed data from 96 women (median age, 47 years) with BC after breast surgery, without significant cardiovascular diseases, who were eligible for adjuvant anthracyclines. They were randomized to a ramipril or control arm. Cardiotoxicity was estimated with repeat echocardiography and themeasurement of troponin I and N‑terminal fragment of the prohormone brain natriuretic peptide (NT‑proBNP) levels over 1‑year follow‑up. Anthracycline‑induced cardiotoxicity was defined as a decrease in left ventricular ejection fraction (LVEF), elevated biomarker levels, and/or occurrence of heart failure (HF) or cardiac death. RESULTS: A decrease in LVEF above 10‑percent points occurred in 6.3% of ramiprilpatients and 18.5% ofcontrols (P = 0.15). No cases of HF, cardiac death, or LVEF decline below 50% were reported. The percentage of patients with elevated NT‑proBNP levels increased with time in controls (P = 0.003) and remained unchanged in the ramipril arm. At the end of follow‑up, an increase in NT‑proBNP levels was more common and decline was less common in the control than ramipril arm (P = 0.01). No significant differences in troponin levels were found between the study arms. Ramipril was well tolerated in normotensive women. CONCLUSIONS: In relatively young women with BC without serious comorbidities, who received anthracyclines, 1‑year treatment with ramipril exerts potentially protective effects on cardiotoxicity assessed with NT‑proBNP levels.
Authors: Aleksandra Grela-Wojewoda; Mirosława Püsküllüoğlu; Beata Sas-Korczyńska; Tomasz Zemełka; Renata Pacholczak-Madej; Wojciech M Wysocki; Tomasz Wojewoda; Agnieszka Adamczyk; Joanna Lompart; Michał Korman; Anna Mucha-Małecka; Marek Ziobro; Ewa Konduracka Journal: Cancers (Basel) Date: 2022-07-10 Impact factor: 6.575